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. 2015:2015:783296.
doi: 10.1155/2015/783296. Epub 2015 Jul 27.

Healthy Chilean Adolescents with HOMA-IR ≥ 2.6 Have Increased Cardiometabolic Risk: Association with Genetic, Biological, and Environmental Factors

R Burrows  1 , P Correa-Burrows  1 , M Reyes  1 , E Blanco  2 , C Albala  1 , S Gahagan  2
Affiliations

Healthy Chilean Adolescents with HOMA-IR ≥ 2.6 Have Increased Cardiometabolic Risk: Association with Genetic, Biological, and Environmental Factors

R Burrows et al. J Diabetes Res. 2015.

Abstract

Objective: To determine the optimal cutoff of the homeostasis model assessment-insulin resistance (HOMA-IR) for diagnosis of the metabolic syndrome (MetS) in adolescents and examine whether insulin resistance (IR), determined by this method, was related to genetic, biological, and environmental factors.

Methods: In 667 adolescents (16.8 ± 0.3 y), BMI, waist circumference, glucose, insulin, adiponectin, diet, and physical activity were measured. Fat and fat-free mass were assessed by dual-energy X-ray absorptiometry. Family history of type 2 diabetes (FHDM) was reported. We determined the optimal cutoff of HOMA-IR to diagnose MetS (IDF criteria) using ROC analysis. IR was defined as HOMA-IR values above the cutoff. We tested the influence of genetic, biological, and environmental factors on IR using logistic regression analyses.

Results: Of the participants, 16% were obese and 9.4 % met criteria for MetS. The optimal cutoff for MetS diagnosis was a HOMA-IR value of 2.6. Based on this value, 16.3% of participants had IR. Adolescents with IR had a significantly higher prevalence of obesity, abdominal obesity, fasting hyperglycemia, and MetS compared to those who were not IR. FHDM, sarcopenia, obesity, and low adiponectin significantly increased the risk of IR.

Conclusions: In adolescents, HOMA-IR ≥ 2.6 was associated with greater cardiometabolic risk.

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Figures

Figure 1
Figure 1
ROC curve to determine the optimal cutoff value of HOMA-IR for MetS diagnosis in healthy adolescents.
Figure 2
Figure 2
Prevalence rates of cardiovascular and metabolic risk factors by HOMA-IR. Error bars are 95% CI. Statistical significant difference by Pearson's Chi2. Significance level: * P < 0.05; ** P < 0.01; *** P<0.001.
See this image and copyright information in PMC

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