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. 2015 Oct 19;54(43):12654-8.
doi: 10.1002/anie.201505714. Epub 2015 Aug 14.

Facile Enzymatic Synthesis of Ketoses

Liuqing Wen  1 , Kenneth Huang  1 , Mohui Wei  1 , Jeffrey Meisner  1   2 , Yunpeng Liu  1 , Kristina Garner  1 , Lanlan Zang  1 , Xuan Wang  1 , Xu Li  1 , Junqiang Fang  3 , Houcheng Zhang  3 , Peng George Wang  4   5
Affiliations

Facile Enzymatic Synthesis of Ketoses

Liuqing Wen et al. Angew Chem Int Ed Engl. .

Abstract

Studies of rare ketoses have been hampered by a lack of efficient preparation methods. A convenient, efficient, and cost-effective platform for the facile synthesis of ketoses is described. This method enables the preparation of difficult-to-access ketopentoses and ketohexoses from common and inexpensive starting materials with high yield and purity and without the need for a tedious isomer separation step.

Keywords: enzymatic synthesis; ketoses; one-pot reactions; phosphorylation; synthetic methods.

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Figures

Figure 1
Figure 1
Twelve naturally occurring ketopentoses and ketohexoses including six (3S)-ketoses and six corresponding (3R)-ketoses
Scheme 1
Scheme 1
One-pot two-step enzymatic synthesis of L-ribulose, D-xylulose and D-tagatose (Route A), and L-xylulose, D-ribulose, D-sorbose, D-psicose and L-tagatose (Route B).
Scheme 2
Scheme 2
One-pot multienzyme reaction for the synthesis of l-fructose.
Scheme 3
Scheme 3
One-pot multienzyme reaction for the synthesis of l-psicose.
See this image and copyright information in PMC

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