hERG potassium channel inhibition by ivabradine requires channel gating

Affiliations

¹ School of Physiology & Pharmacology, Biomedical Sciences Building, University Walk, Bristol BS8 1TD, UK.
² Department of Cardiovascular Sciences, Cardiology Group, University of Leicester, Glenfield Hospital, Leicester LE3 9QP, UK.
³ Department of Cell Physiology and Pharmacology, Maurice Shock Medical Sciences Building, University Road, PO Box 138, Leicester LE1 9HN, UK.
⁴ School of Biochemistry, Biomedical Sciences Building, University Walk, Bristol BS8 1TD, UK.
⁵ Department of Cardiovascular Sciences, Cardiology Group, University of Leicester, Glenfield Hospital, Leicester LE3 9QP, UK; NIHR Leicester Cardiovascular Biomedical Research Unit, Leicester LE3 9QP, UK.
⁶ School of Physiology & Pharmacology, Biomedical Sciences Building, University Walk, Bristol BS8 1TD, UK. Electronic address: jules.hancox@bristol.ac.uk.

Comment

Dario Melgari et al. J Mol Cell Cardiol. 2015 Oct.

. 2015 Oct:87:126-8.

doi: 10.1016/j.yjmcc.2015.08.002. Epub 2015 Aug 11.

¹ School of Physiology & Pharmacology, Biomedical Sciences Building, University Walk, Bristol BS8 1TD, UK.
² Department of Cardiovascular Sciences, Cardiology Group, University of Leicester, Glenfield Hospital, Leicester LE3 9QP, UK.
³ Department of Cell Physiology and Pharmacology, Maurice Shock Medical Sciences Building, University Road, PO Box 138, Leicester LE1 9HN, UK.
⁴ School of Biochemistry, Biomedical Sciences Building, University Walk, Bristol BS8 1TD, UK.
⁵ Department of Cardiovascular Sciences, Cardiology Group, University of Leicester, Glenfield Hospital, Leicester LE3 9QP, UK; NIHR Leicester Cardiovascular Biomedical Research Unit, Leicester LE3 9QP, UK.
⁶ School of Physiology & Pharmacology, Biomedical Sciences Building, University Walk, Bristol BS8 1TD, UK. Electronic address: jules.hancox@bristol.ac.uk.

No abstract available

Comment in

In response to Melgari et al. "hERG potassium channel inhibition by ivabradine requires channel gating".
Lees-Miller JP, Guo J, Wang Y, Perissinotti LL, Noskov SY, Duff HJ. Lees-Miller JP, et al. J Mol Cell Cardiol. 2015 Oct;87:192-3. doi: 10.1016/j.yjmcc.2015.08.003. Epub 2015 Aug 20. J Mol Cell Cardiol. 2015. PMID: 26299838 No abstract available.

Ivabradine prolongs phase 3 of cardiac repolarization and blocks the hERG1 (KCNH2) current over a concentration-range overlapping with that required to block HCN4.
Lees-Miller JP, Guo J, Wang Y, Perissinotti LL, Noskov SY, Duff HJ. Lees-Miller JP, et al. J Mol Cell Cardiol. 2015 Aug;85:71-8. doi: 10.1016/j.yjmcc.2015.05.009. Epub 2015 May 16. J Mol Cell Cardiol. 2015. PMID: 25986146