Malaria-Induced B Cell Genomic Instability
- PMID: 26276622
- DOI: 10.1016/j.cell.2015.07.051
Malaria-Induced B Cell Genomic Instability
Abstract
Nussenzweig and colleagues evaluate genomic instability and germinal center derived lymphomagenesis in mice infected with Plasmodium to recreate some of the hallmark characteristics of Burkitt lymphoma, a form of cancer more common in parts of Africa where malaria is endemic.
Copyright © 2015 Elsevier Inc. All rights reserved.
Comment on
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Chromosome translocation, B cell lymphoma, and activation-induced cytidine deaminase.Annu Rev Pathol. 2013 Jan 24;8:79-103. doi: 10.1146/annurev-pathol-020712-164004. Epub 2012 Sep 4. Annu Rev Pathol. 2013. PMID: 22974238 Review.
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