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Review
. 2015 Oct:24:52-8.
doi: 10.1016/j.coph.2015.07.005. Epub 2015 Aug 14.

An overview of the clinical application of antisense oligonucleotides for RNA-targeting therapies

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Review

An overview of the clinical application of antisense oligonucleotides for RNA-targeting therapies

Graham McClorey et al. Curr Opin Pharmacol. 2015 Oct.

Abstract

Despite the discovery more than two decades ago that antisense oligonucleotides (ASOs) could be used to modulate protein expression, there have been only two antisense drugs approved for clinical use till date. Despite this low success rate, the antisense field is undergoing resurgence due to the development of more potent and nuclease resistant chemistries, as well as nanoparticle delivery systems that enhance delivery to target tissues. In this review, we introduce the predominant therapeutic strategies in the antisense field whilst highlighting recent clinical findings that demonstrate the significant potential of these approaches for development of novel therapies in several diseases.

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