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. 2015 Dec 1;121(23):4181-9.
doi: 10.1002/cncr.29643. Epub 2015 Aug 17.

Incidence of testicular germ cell tumors among US men by census region

Armen A Ghazarian  1 , Britton Trabert  1 , Barry I Graubard  1 , Stephen M Schwartz  2   3 , Sean F Altekruse  4 , Katherine A McGlynn  1
Affiliations

Incidence of testicular germ cell tumors among US men by census region

Armen A Ghazarian et al. Cancer. .

Abstract

Background: The incidence of testicular germ cell tumors (TGCTs) in the United States is notably higher among white men versus other men. Previously, however, it was reported that rates were rising among Hispanics in certain areas. To determine whether this finding was evident in a wider area of the United States, data from 39 US cancer registries were examined.

Methods: Racial/ethnic-specific incidence rates per 100,000 man-years were calculated overall and by census region for the period of 1998-2011. Annual percentage changes (APCs) were estimated, and joinpoint models were fit. Differences in incidence by region were examined with the Wald test.

Results: From 1998 to 2011, 88,993 TGCTs were recorded. The TGCT incidence was highest among non-Hispanic whites (6.57 per 100,000), who were followed by Hispanics (3.88), American Indians/Alaska Natives (2.88), Asians/Pacific Islanders (A/PIs; 1.60), and non-Hispanic blacks (1.20). The incidence significantly increased among Hispanics (APC, 2.31; P < .0001), with rates rising in all regions except the South. Rates rose slightly among non-Hispanic whites (APC, 0.51; P = .0076). Significant differences in rates by region were seen for Hispanics (P = .0001), non-Hispanic whites (P < .0001), and A/PIs (P < .0001), with the highest rates among Hispanics in the West and with the highest rates among non-Hispanic whites and A/PIs in the Northeast.

Conclusions: Although the incidence of TGCTs remained highest among non-Hispanic whites between 1998 and 2011, the greatest increase was experienced by Hispanics. Rising rates of TGCTs among Hispanics in the United States suggest that future attention is warranted. Reasons for the increase may include variability in birthplace, changing exposures, genetic susceptibility, and the length of US residence.

Keywords: North American Association of Central Cancer Registries (NAACCR); ethnic groups; incidence; testicular cancer; testicular germ cell tumor (TGCT); trends.

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Conflict of interest statement

The authors declare no conflicts of interest or financial disclosures

CONFLICT OF INTEREST DISCLOSURES

The authors declare no competing interests and have no financial disclosures.

Figures

Figure 1
Figure 1
Census Regions of the United States
Figure 2
Figure 2
Age-adjusted incidence rates of testicular germ cell tumors among non-Hispanic white, Hispanic (All Races), non-Hispanic Black, Asian/Pacific Islander (A/PI), and American Indian/Alaska Native (AI/AN) men, SEER/NPCR Registries, 1998–2011
Figure 3
Figure 3
Age-adjusted incidence rates of testicular germ cell tumors by census region, SEER/NPCR Registries, 1998–2011 a. Testicular Germ Cell Tumors b. Seminoma c. Nonseminoma
See this image and copyright information in PMC

References

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