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. 2016 Feb;137(2):627-629.e2.
doi: 10.1016/j.jaci.2015.06.041. Epub 2015 Aug 15.

GATA3 haploinsufficiency does not block allergic sensitization or atopic disease

Monica G Lawrence  1 , Jennifer W Leiding  2 , Jonathan J Lyons  3 , Amy P Hsu  4 , Celeste C Nelson  3 , Nina Jones  5 , Alan Fitzgerald  4 , Wade W Chien  6 , Lisa Workman  1 , Thomas A Platts-Mills  1 , Carmen Brewer  7 , Rachel I Gafni  8 , Kelly D Stone  3 , Joshua D Milner  3 , Steven M Holland  9
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GATA3 haploinsufficiency does not block allergic sensitization or atopic disease

Monica G Lawrence et al. J Allergy Clin Immunol. 2016 Feb.
No abstract available

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Figures

Fig. 1
Fig. 1
Results of a six-hour stimulation of PBMCs with PMA and ionomycin in the presence of brefeldin A, followed by fixation, permeabilization and staining for intracellular cytokines. Data shown represent mean of 3 independent experiments for GATA3+/− patients; included for comparison are age and sex matched healthy controls.
Fig. 2
Fig. 2
CD4+ naïve T cells were subject to Th0 (anti-CD3/CD28 and IL-2) or Th2 (anti-CD3/CD28, IL-2, IL-4, anti-IFN-γ, anti-IL-10) skewing conditions prior to staining for expression of TBET and GATA3. n=3–5 independent experiments. (a) Geometric mean fluorescent intensity (MFI) of GATA3 under Th0 and Th2 conditions (representative data). (b) Fold increase of GATA3 MFI under Th2 conditions compared to Th0 conditions.
See this image and copyright information in PMC

References

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