CXCL12 catches T-ALL at the entrance of the bone marrow

Tatsuki Sugiyama¹, Takashi Nagasawa²

Affiliations

¹ Department of Immunobiology and Hematology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan; Japan Science and Technology Agency (JST), Core Research for Evolutional Science and Technology (CREST), 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan.
² Department of Immunobiology and Hematology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan; Japan Science and Technology Agency (JST), Core Research for Evolutional Science and Technology (CREST), 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan. Electronic address: tnagasa@frontier.kyoto-u.ac.jp.

PMID: 26282886
DOI: 10.1016/j.it.2015.08.001

Comment

CXCL12 catches T-ALL at the entrance of the bone marrow

Tatsuki Sugiyama et al. Trends Immunol. 2015 Sep.

. 2015 Sep;36(9):504-6.

doi: 10.1016/j.it.2015.08.001. Epub 2015 Aug 14.

Authors

Tatsuki Sugiyama¹, Takashi Nagasawa²

Affiliations

¹ Department of Immunobiology and Hematology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan; Japan Science and Technology Agency (JST), Core Research for Evolutional Science and Technology (CREST), 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan.
² Department of Immunobiology and Hematology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan; Japan Science and Technology Agency (JST), Core Research for Evolutional Science and Technology (CREST), 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan. Electronic address: tnagasa@frontier.kyoto-u.ac.jp.

PMID: 26282886
DOI: 10.1016/j.it.2015.08.001

Abstract

A fraction of patients with T-cell acute lymphoblastic leukemias (T-ALLs) relapse and have a dismal prognosis. Two recent papers in Cancer Cell reveal that endothelial cell-derived CXCL12 is essential for bone marrow involvement and tumor progression in T-ALL patients, suggesting that this chemokine axis presents a potential therapeutic target for the treatment of T-ALL.

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CXCL12-Producing Vascular Endothelial Niches Control Acute T Cell Leukemia Maintenance.
Pitt LA, Tikhonova AN, Hu H, Trimarchi T, King B, Gong Y, Sanchez-Martin M, Tsirigos A, Littman DR, Ferrando AA, Morrison SJ, Fooksman DR, Aifantis I, Schwab SR. Pitt LA, et al. Cancer Cell. 2015 Jun 8;27(6):755-68. doi: 10.1016/j.ccell.2015.05.002. Cancer Cell. 2015. PMID: 26058075 Free PMC article.

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CXCL12 catches T-ALL at the entrance of the bone marrow

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CXCL12 catches T-ALL at the entrance of the bone marrow

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