Reply: To PMID 25559091

Affiliations

¹ Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN.
² Department of Medicine, Neurology, Ophthalmology, and Genetics and Genomics, Boston University School of Medicine, Boston, MA.

Comment

Kwangsik Nho et al. Ann Neurol. 2015 Nov.

. 2015 Nov;78(5):836-7.

doi: 10.1002/ana.24505. Epub 2015 Sep 22.

¹ Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN.
² Department of Medicine, Neurology, Ophthalmology, and Genetics and Genomics, Boston University School of Medicine, Boston, MA.

No abstract available

Conflict of interest statement

Potential Conflicts of Interest: Nothing to report.

Protective variant for hippocampal atrophy identified by whole exome sequencing.
Nho K, Kim S, Risacher SL, Shen L, Corneveaux JJ, Swaminathan S, Lin H, Ramanan VK, Liu Y, Foroud TM, Inlow MH, Siniard AL, Reiman RA, Aisen PS, Petersen RC, Green RC, Jack CR Jr, Weiner MW, Baldwin CT, Lunetta KL, Farrer LA; MIRAGE (Multi-Institutional Research on Alzheimer Genetic Epidemiology) Study; Furney SJ, Lovestone S, Simmons A, Mecocci P, Vellas B, Tsolaki M, Kloszewska I, Soininen H; AddNeuroMed Consortium; McDonald BC, Farlow MR, Ghetti B; Indiana Memory and Aging Study; Huentelman MJ, Saykin AJ; Alzheimer's Disease Neuroimaging Initiative. Nho K, et al. Ann Neurol. 2015 Mar;77(3):547-52. doi: 10.1002/ana.24349. Epub 2015 Feb 14. Ann Neurol. 2015. PMID: 25559091 Free PMC article.
REST rs3796529 variant does not confer susceptibility to Alzheimer's disease.
Li K, Jiang Q, Xu A, Liu G. Li K, et al. Ann Neurol. 2015 Nov;78(5):835-6. doi: 10.1002/ana.24503. Epub 2015 Sep 22. Ann Neurol. 2015. PMID: 26285156 No abstract available.

1. Lambert JC, Ibrahim-Verbaas CA, Harold D, et al. Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease. Nat Genet. 2013;45:1452–1458. - PMC - PubMed
1. Nho K, Kim S, Risacher SL, et al. Protective variant for hippocampal atrophy identified by whole exome sequencing. Ann Neurol. 2015;77:547–552. - PMC - PubMed