Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2015 Oct;149(5):1265-1274.e3.
doi: 10.1053/j.gastro.2015.08.006. Epub 2015 Aug 15.

Diagnostic and Prognostic Microbial Biomarkers in Inflammatory Bowel Diseases

Marla Dubinsky  1 , Jonathan Braun  2
Affiliations
Review

Diagnostic and Prognostic Microbial Biomarkers in Inflammatory Bowel Diseases

Marla Dubinsky et al. Gastroenterology. 2015 Oct.

Abstract

The microbiome plays multifaceted roles in the pathogenesis of inflammatory bowel diseases (IBD). Accordingly, the clinical challenge of patient heterogeneity in disease phenotype and response to treatment should in part be addressed by biomarkers that detect the host response to microbiota, and the levels of microbial taxa and products eliciting the host response in susceptible individuals. Molecular analysis has revealed much evidence for microbial taxonomic membership and microbial products in association with IBD, but their utility as clinical biomarkers is still in its infancy. A rich area of progress has been the development and validation of host serologic microbial biomarkers, which have achieved a distinctive position in the diagnosis and prognosis in IBD, and as a template for defining other categories of microbial biomarkers in disease state and phenotype.

Keywords: Gastrointestinal Disease; Genetics; Genomics; Immunology.

PubMed Disclaimer

Conflict of interest statement

of Competing Interests: Marla Dubinsky: Consultant, Prometheus Laboratories Inc. Jonathan Braun: Consultant, Janssen Pharmaceuticals, Inc.; Eli Lilly and Company, Inc.

Figures

Figure 1
Figure 1
Web-based tool to show patients their individualized probability of developing a complication over a 3-year period.
See this image and copyright information in PMC

References

    1. Kaser A, Zeissig S, Blumberg RS. Inflammatory bowel disease. Annu Rev Immunol. 2010;28:573–621. - PMC - PubMed
    1. Sellon RK, Tonkonogy S, Schultz M, et al. Resident enteric bacteria are necessary for development of spontaneous colitis and immune system activation in interleukin-10-deficient mice. Infect Immun. 1998;66:5224–31. - PMC - PubMed
    1. Garrett WS, Lord GM, Punit S, et al. Communicable ulcerative colitis induced by T-bet deficiency in the innate immune system. Cell. 2007;131:33–45. - PMC - PubMed
    1. Elinav E, Strowig T, Kau AL, et al. NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis. Cell. 2011;145:745–57. - PMC - PubMed
    1. Jacobs J, Braun J. Host genes and their effect on the intestinal microbiome garden. Genome Med. 2014;6:119. - PMC - PubMed

Publication types

MeSH terms