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. 2015 Aug 13;7(8):6780-96.
doi: 10.3390/nu7085308.

Prevalence and Correlates of Vitamin D Deficiency and Insufficiency in Luxembourg Adults: Evidence from the Observation of Cardiovascular Risk Factors (ORISCAV-LUX) Study

Ala'a Alkerwi  1 , Nicolas Sauvageot  2 , Georges Gilson  3 , Saverio Stranges  4
Affiliations

Prevalence and Correlates of Vitamin D Deficiency and Insufficiency in Luxembourg Adults: Evidence from the Observation of Cardiovascular Risk Factors (ORISCAV-LUX) Study

Ala'a Alkerwi et al. Nutrients. .

Abstract

Evidence on vitamin D status and related risk factors in Luxembourg adults is lacking. This study aimed to determine the prevalence of vitamin D deficiency and insufficiency and related risk factors among healthy adults in Luxembourg. Based on clinicians' observations, it was hypothesized that vitamin D deficiency and insufficiency might be common in our population, constituting a significant public health concern. A nationally representative random sample of 1432 adults was enrolled in the ORISCAV-LUX study, 2007-2008. The participants were divided into four categories according to their serum concentrations of 25-hydroxyvitamin D [25(OH)D]. Descriptive, univariate and multivariate statistical analyses used weighted methods to account for the stratified sampling scheme. Only 17.1% of the population had a "desirable" serum 25(OH)D level ≥75 nmol/L, whereas 27.1% had "inadequate" [serum 25(OH)D level 50-74 nmol/L], 40.4% had "insufficient" [serum 25(OH)D level 25-49 nmol/L], and 15.5% had "deficient" [serum 25(OH)D level <25 nmol/L)]. The prevalence of vitamin D deficiency was greater among current smokers, obese subjects, those having reduced HDL-cholesterol level and fair/poor self-perception of health, compared to their counterparts. The prevalence of vitamin D insufficiency was additionally higher among nondrinkers of alcohol, Portuguese and subjects from non-European countries. The final multivariate logistic regression analyses revealed that smoking status and obesity were independent correlates of vitamin D deficiency and insufficiency, respectively. Inadequate vitamin D status is highly prevalent among adults in Luxembourg and is associated with specific lifestyle factors. Along with the effect of vitamin D deficiency and insufficiency on the risk of several diseases, cancer and mortality, our findings have practical implications for public health dietary recommendations, and of particular importance for healthcare practitioners and policy makers.

Keywords: cross-sectional; population-based study; vitamin D deficiency.

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Figures

Figure 1
Figure 1
Total, sex- and age-specific prevalence of different categories of vitamin D, among the adults in Luxembourg, ORISCAV-LUX study.
See this image and copyright information in PMC

References

    1. Palacios C. The role of nutrients in bone health, from A to Z. Crit. Rev. Food Sci. Nutr. 2006;46:621–628. doi: 10.1080/10408390500466174. - DOI - PubMed
    1. Ross A.C., Manson J.E., Abrams S.A., Aloia J.F., Brannon P.M., Clinton S.K., Durazo-Arvizu R.A., Gallagher J.C., Gallo R.L., Jones G., et al. The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: What clinicians need to know. J. Clin. Endocrinol. Metab. 2011;96:53–58. doi: 10.1210/jc.2010-2704. - DOI - PMC - PubMed
    1. Spiro A., Buttriss J.L. Vitamin D: An overview of vitamin D status and intake in Europe. Nutr. Bull. BNF. 2014;39:322–350. doi: 10.1111/nbu.12108. - DOI - PMC - PubMed
    1. Dunnigan M.G., Henderson J.B., Hole D. Serum 25-hydroxyvitamin D and colon cancer. Lancet. 1990;335:111–112. doi: 10.1016/0140-6736(90)90578-S. - DOI - PubMed
    1. Garland C.F., Garland F.C., Gorham E.D., Lipkin M., Newmark H., Mohr S.B., Holick M.F. The role of vitamin D in cancer prevention. Am. J. Public Health. 2006;96:252–261. doi: 10.2105/AJPH.2004.045260. - DOI - PMC - PubMed

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