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. 2015 Aug 20:16:368.
doi: 10.1186/s13063-015-0905-9.

Core Outcomes in Ventilation Trials (COVenT): protocol for a core outcome set using a Delphi survey with a nested randomised trial and observational cohort study

Bronagh Blackwood  1 , Suzanne Ringrow  2 , Mike Clarke  3 , John Marshall  4 , Louise Rose  5   6   7   8   9 , Paula Williamson  10 , Danny McAuley  11   12
Affiliations

Core Outcomes in Ventilation Trials (COVenT): protocol for a core outcome set using a Delphi survey with a nested randomised trial and observational cohort study

Bronagh Blackwood et al. Trials. .

Abstract

Background: Among clinical trials of interventions that aim to modify time spent on mechanical ventilation for critically ill patients there is considerable inconsistency in chosen outcomes and how they are measured. The Core Outcomes in Ventilation Trials (COVenT) study aims to develop a set of core outcomes for use in future ventilation trials in mechanically ventilated adults and children.

Methods/design: We will use a mixed methods approach that incorporates a randomised trial nested within a Delphi study and a consensus meeting. Additionally, we will conduct an observational cohort study to evaluate uptake of the core outcome set in published studies at 5 and 10 years following core outcome set publication. The three-round online Delphi study will use a list of outcomes that have been reported previously in a review of ventilation trials. The Delphi panel will include a range of stakeholder groups including patient support groups. The panel will be randomised to one of three feedback methods to assess the impact of the feedback mechanism on subsequent ranking of outcomes. A final consensus meeting will be held with stakeholder representatives to review outcomes.

Discussion: The COVenT study aims to develop a core outcome set for ventilation trials in critical care, explore the best Delphi feedback mechanism for achieving consensus and determine if participation increases use of the core outcome set in the long term.

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Figures

Fig. 1
Fig. 1
Flowchart of the Delphi study and nested randomised controlled trial
Fig. 2
Fig. 2
Flowchart of randomisation in the observational cohort study. MV, mechanical ventilation
See this image and copyright information in PMC

References

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    1. Rose L, Schultz MJ, Cardwell CR, Jouvet P, McAuley DF, Blackwood B. Automated versus non-automated weaning for reducing the duration of mechanical ventilation for critically ill adults and children. Cochrane Database Syst Rev. 2014;6:CD009235. - PMC - PubMed
    1. Blackwood B, Clarke M, McAuley DF, McGuigan PJ, Marshall JC, Rose L. How outcomes are defined in clinical trials of mechanically ventilated adults and children. Am J Respir Crit Care Med. 2014;189(8):886–93. doi: 10.1164/rccm.201309-1645PP. - DOI - PubMed
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