Developmental evidence for modality-dependent P300 generators: a normative study

Abstract

The behavior of the early and late components of the event-related brain potential (ERP) elicited by auditory and visual stimuli was studied in 40 normal females between the ages of 7 and 20. The ERPs were collected using two different tasks (i.e.,count and reaction time) in an oddball paradigm. Analysis of the early component (i.e., N1, P2, N2) latencies revealed small but significant decreases with age in the visual modality but no change in the auditory modality. Except for the visual N1, early component amplitudes did not change significantly over this age range. The results showed that auditory and visual P300 latencies, but not amplitudes, changed at significantly different rates over this age range. P300 latencies in the auditory modality showed a relatively abrupt change around age 12, after which P300 latencies changed little and were essentially at their adult levels. The latencies of visual P300s showed a much smaller and more steady decrease with age. Thus visual P300 latencies were shorter than auditory P300s in young children but longer than auditory P300s in older children. Significantly different scalp distributions were found for auditory and visual P300s. Although all P300 activity was maximal over parietal scalp, visual P300s were significantly larger than auditory P300s over central and frontal scalp. The developmental differences, combined with the presence of significantly different scalp topographies for auditory and visual P300s, provide convergent evidence that P300 activity is not independent of the modality of the eliciting stimulus.