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. 2015 Aug 20;9(8):e0003897.
doi: 10.1371/journal.pntd.0003897. eCollection 2015 Aug.

Should the Goal for the Treatment of Soil Transmitted Helminth (STH) Infections Be Changed from Morbidity Control in Children to Community-Wide Transmission Elimination?

Roy M Anderson  1 , Hugo C Turner  1 , James E Truscott  1 , T Déirdre Hollingsworth  2 , Simon J Brooker  3
Affiliations

Should the Goal for the Treatment of Soil Transmitted Helminth (STH) Infections Be Changed from Morbidity Control in Children to Community-Wide Transmission Elimination?

Roy M Anderson et al. PLoS Negl Trop Dis. .
No abstract available

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Conflict of interest statement

I have read the journal’s policy and the authors of this manuscript have the following competing interests: RMA is non-executive member of the board of GlaxoSmithKline (GSK). GlaxoSmithKline played no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. This does not alter our adherence to all PLOS policies on sharing data and materials.

Figures

Fig 1
Fig 1. Cross-sectional surveys of the mean intensity of infection in different age groupings for A. lumbricoides (A), T. trichiura (B), and hookworm (C) based on worm expulsion studies.
These are typical age intensity profiles for the three most important STH species, where the colours denote the age groupings: pre-SAC (blue), SAC (red), and adults (orange). Data for A from [25], data for B [26], and data for C [27]. The inset in Graph C represents five worm expulsion studies of Necator americanus showing consistent patterns in a rise in burden with age in different geographical locations [28].
Fig 2
Fig 2. Impact of different treatment stratgies on the mean number of worms in different age groupings.
The coloured lines represent different treatment strategies: green—annual community-wide MDA (75% coverage of all age groupings (pre-SAC, SAC, and adults) and 95% drug efficacy); red—biannual age group targeted MDA (pre-SAC and SAC with 75% coverage and 95% drug efficacy); and blue—annual age group targeted MDA (pre-SAC and SAC with 75% coverage and 95% drug efficacy). Graphs A–C and D–F correspond to Hookworm and Ascaris respectively. Graphs A and D record the overall mean number of worms across all ages. Graphs B and E record the mean number of worms in children (pre-SAC and SAC, 2–15-year-olds). Graphs C and F record the mean number of worms in adults (>15 year olds). Calculations based on a basic reproductive number, Ro, of 2.5 (medium to high transmission setting). Model parameters described in [13].
See this image and copyright information in PMC

References

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    1. World Health Organization (2006) Preventive Chemotheraphy in Human Helminthiasis. Geneva, Switzerland: World Health Organization; Available: http://whqlibdoc.who.int/publications/2006/9241547103_eng.pdf. Accessed 27th April 2015.
    1. The London Declaration on Neglected Tropical Diseases. Available: www.UnitingToCombatNTDs.org. Accessed 27th April 2015.
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