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Review
. 2015 Oct;56(10):1486-9.
doi: 10.1111/epi.13107. Epub 2015 Aug 21.

Epileptic encephalopathies: Optimizing seizure control and developmental outcome

Lara Jehi  1 , Elaine Wyllie  1 , Orrin Devinsky  2
Affiliations
Review

Epileptic encephalopathies: Optimizing seizure control and developmental outcome

Lara Jehi et al. Epilepsia. 2015 Oct.

Abstract

Cognitive and developmental outcomes in patients with epileptic encephalopathy are hypothesized to result from an interplay between the underlying epileptic pathologic substrate and the acquired consequences of frequent and repetitive seizures and epileptiform discharges that often straddle the interictal and ictal boundaries. This article briefly reviews the evidence related to this assumption, presents critical questions that need to be answered to clarify this relationship, and advances a set of concrete steps that may help improve developmental patient outcomes.

Keywords: Development; Epileptic encephalopathy; Pediatric epilepsy.

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Comment in

  • The other side of epilepsy.
    Tuchman R, Loring DW. Tuchman R, et al. Epilepsia. 2015 Oct;56(10):1490-1. doi: 10.1111/epi.13104. Epub 2015 Aug 21. Epilepsia. 2015. PMID: 26293340 No abstract available.

MeSH terms