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Review
. 2015 Aug 21:13:34.
doi: 10.1186/s12969-015-0033-9.

Review article: BK virus in systemic lupus erythematosus

Nirupama Gupta  1 , Robert M Lawrence  2 , Cuong Nguyen  3 , Renee F Modica  4
Affiliations
Review

Review article: BK virus in systemic lupus erythematosus

Nirupama Gupta et al. Pediatr Rheumatol Online J. .

Abstract

BK virus (BKV) is a human polyomavirus with a seroprevalence of 60-80 % in the general population. In renal transplant patients, it is known to cause renal failure, ureteric stenosis and hemorrhagic cystitis. In bone marrow transplant patients, it is evident that BKV can also cause hemorrhagic cystitis along with BK virus nephropathy (BKVN) in the native kidneys, with subsequent renal failure. However, little is known about BVKN in non-transplanted immune-compromised patients, such as systemic lupus erythematosus (SLE) who may have underlying nephritis and have a compromised immune system due to therapy and/or systemic illness. Thus, this article will focus on the clinical aspects of BKV and its association in patients with SLE.

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Figures

Fig. 1
Fig. 1
A native renal biopsy with multiple intranuclear BK viral inclusions (a) and positive staining for SV40 T antigen (b) in the tubular epithelial cells (identified by the arrows). There is also extensive interstitial fibrosis and tubular atrophy, along with prominence of inflammatory cells in the interstitium and tubular cells
See this image and copyright information in PMC

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