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Comment
. 2015 Aug 17;25(16):R728-31.
doi: 10.1016/j.cub.2015.06.064.

Neurodegeneration: A Leg Up on TDP-43

Matthew D Figley  1 , Aaron D Gitler  2
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Free article
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Neurodegeneration: A Leg Up on TDP-43

Matthew D Figley et al. Curr Biol. .
Free article

Abstract

TDP-43 is a key disease protein for amyotrophic lateral sclerosis but how it drives motor neuron degeneration remains unresolved. A new study has modeled TDP-43 age-dependent axonal death in the Drosophila leg and used a powerful forward genetic screen to identify three novel suppressor genes.

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