Investigating age-related changes in anterior and posterior neural activity throughout the information processing stream

Abstract

Event-related potential (ERP) and other functional imaging studies often demonstrate age-related increases in anterior neural activity and decreases in posterior activity while subjects carry out task demands. It remains unclear whether this "anterior shift" is limited to late cognitive operations like those indexed by the P3 component, or is evident during other stages of information processing. The temporal resolution of ERPs provided an opportunity to address this issue. Temporospatial principal component analysis (PCA) was used to identify underlying components that may be obscured by overlapping ERP waveforms. ERPs were measured during a visual oddball task in 26 young, 26 middle-aged, and 29 old subjects who were well-matched for IQ, executive function, education, and task performance. PCA identified six anterior factors peaking between ∼140 ms and 810 ms, and four posterior factors peaking between ∼300 ms and 810 ms. There was an age-related increase in the amplitude of anterior factors between ∼200 and 500 ms, and an age-associated decrease in amplitude of posterior factors after ∼500 ms. The increase in anterior processing began as early as middle-age, was sustained throughout old age, and appeared to be linear in nature. These results suggest that age-associated increases in anterior activity occur after early sensory processing has taken place, and are most prominent during a period in which attention is being marshaled to evaluate a stimulus. In contrast, age-related decreases in posterior activity manifest during operations involved in stimulus categorization, post-decision monitoring, and preparation for an upcoming event.

Keywords: Aging; Anterior; ERP; Posterior; Principal component analysis.

Fig. 1

Illustration of an experimental run.

Fig. 2

Illustration of the grand average ERP waveforms in response to target stimuli at (a) anterior and (b) posterior sites.

Fig. 3

Waveforms and scalp topographies of each of the (a) anterior and (b) posterior PCA factors in response to target stimuli. Please note that the scales used differ across factors.

Fig. 4

Bar graphs depicting the mean ± SEM amplitude for each of the (a) anterior and (b) posterior PCA factors within in age group.