Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Observational Study
. 2015 Nov:96:126-34.
doi: 10.1016/j.resuscitation.2015.07.037. Epub 2015 Aug 19.

Long-term evolution after in-hospital cardiac arrest in children: Prospective multicenter multinational study

Jimena Del Castillo  1 , Jesús López-Herce  2 , Martha Matamoros  3 , Sonia Cañadas  4 , Ana Rodríguez-Calvo  5 , Corrado Cecchetti  6 , Antonio Rodriguez-Núñez  7 , Angel Carrillo Álvarez  1 ; Iberoamerican Pediatric Cardiac Arrest Study Network RIBEPCI
Collaborators, Affiliations
Observational Study

Long-term evolution after in-hospital cardiac arrest in children: Prospective multicenter multinational study

Jimena Del Castillo et al. Resuscitation. 2015 Nov.

Abstract

Objective: The main objective was to study survival and neurologic evolution of children who suffered in-hospital pediatric cardiac arrest (CA). The secondary objective was to analyze the influence of risk factors on the long term outcome after CA.

Methods: prospective, international, observational, multicentric study in 48 hospitals of 12 countries. CA in children between 1 month and 18 years were analyzed using the Utstein template. Survival and neurological state measured by Pediatric Cerebral Performance Category (PCPC) scale one year after hospital discharge was evaluated.

Results: 502 patients with in-hospital CA were evaluated. 197 of them (39.2%) survived to hospital discharge. PCPC at hospital discharge was available in 156 of survivors (79.2%). 76.9% had good neurologic state (PCPC 1-2) and 23.1% poor PCPC values (3-6). One year after cardiac arrest we could obtain data from 144 patients (28.6%). PCPC was available in 116 patients. 88 (75.9%) had a good neurologic evaluation and 28 (24.1%) a poor one. A neurological deterioration evaluated by PCPC scale was observed in 40 patients (7.9%). One year after cardiac arrest PCPC scores compared to hospital discharge had worsen in 7 patients (6%), remained constant in 103 patients (88.8%) and had improved in 6 patients (5.2%).

Conclusion: Survival one year after cardiac arrest in children after in-hospital cardiac arrest is high. Neurologic outcome of these children a year after cardiac arrest is mostly the same as after hospital discharge. The factors associated with a worst long-term neurological outcome are the etiology of arrest being a traumatic or neurologic illness, and the persistency of higher lactic acid values 24h after ROSC. A standardised basic protocol even practicable for lower developed countries would be a first step for the new multicenter studies.

Keywords: Cardiac arrest; Children; In-hospital cardiac arrest; Long-term outcome; Resuscitation.

PubMed Disclaimer

Publication types

LinkOut - more resources