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Comment
. 2015 Oct;309(8):H1235-6.
doi: 10.1152/ajpheart.00647.2015. Epub 2015 Aug 21.

Can ErbB2 overexpression protect against doxorubicin cardiotoxicity?

Petra Rocic  1
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Comment

Can ErbB2 overexpression protect against doxorubicin cardiotoxicity?

Petra Rocic. Am J Physiol Heart Circ Physiol. 2015 Oct.
No abstract available

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References

    1. Belmonte F, Das S, Sysa-Shah P, Sivakumaran V, Stanley B, Guo X, Paolocci N, Aon MA, Nagane M, Kuppusamy P, Steenbergen C, Gabrielson K. ErbB2 overexpression upregulates antioxidant enzymes, reduces basal levels of reactive oxygen species, and protects against doxorubicin cardiotoxicity. Am J Physiol Heart Circ Physiol 309, 2015. doi:10.1152/ajpheart.00517.2014. - DOI - PMC - PubMed
    1. Bugger H, Guzman C, Zechner C, Palmeri M, Russell KS, Russell RR 3rd. Uncoupling protein downregulation in doxorubicin-induced heart failure improves mitochondrial coupling but increases reactive oxygen species generation. Cancer Chemother Pharmacol 67: 1381–1388, 2011. - PMC - PubMed
    1. Crone SA, Zhao YY, Fan L, Gu Y, Minamisawa S, Liu Y, Peterson KL, Chen J, Kahn R, Condorelli G, Ross J Jr, Chien KR, Lee KF. ErbB2 is essential in the prevention of dilated cardiomyopathy. Nat Med 8: 459–465, 2002. - PubMed
    1. Ewer MS, O'Shaughnessy JA. Cardiac toxicity of trastuzumab-related regimens in HER2-overexpressing breast cancer. Clin Breast Cancer 7: 600–607, 2007. - PubMed
    1. Gordon LI, Burke MA, Singh AT, Prachand S, Lieberman ED, Sun L, Naik TJ, Prasad SV, Ardehali H. Blockade of the erbB2 receptor induces cardiomyocyte death through mitochondrial and reactive oxygen species-dependent pathways. J Biol Chem 284: 2080–2087, 2009. - PMC - PubMed

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