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Review
. 2015 Jun;15 Suppl(0):S167-9.
doi: 10.1016/j.clml.2015.02.010.

Pre-clinical Specificity and Safety of UC-961, a First-In-Class Monoclonal Antibody Targeting ROR1

Michael Y Choi  1 , George F Widhopf 2nd  1 , Christina C N Wu  1 , Bing Cui  1 , Fitzgerald Lao  1 , Anil Sadarangani  2 , Joy Cavagnaro  3 , Charles Prussak  1 , Dennis A Carson  1 , Catriona Jamieson  2 , Thomas J Kipps  4
Affiliations
Review

Pre-clinical Specificity and Safety of UC-961, a First-In-Class Monoclonal Antibody Targeting ROR1

Michael Y Choi et al. Clin Lymphoma Myeloma Leuk. 2015 Jun.

Abstract

Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is an oncoembryonic antigen. Because of its expression on the cell surface of leukemia cells from patients with chronic lymphocytic leukemia (CLL), but not on normal B-cells or other postpartum tissues, ROR1 is an attractive candidate for targeted therapies. UC-961 is a first-in-class humanized monoclonal antibody that binds the extracellular domain of ROR1. In this article we outline some of the preclinical studies leading to an investigational new drug designation, enabling clinical studies in patients with CLL.

Keywords: AKT; CLL; Cirmtuzumab; Wnt receptor; cancer stem cell.

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Figures

Figure 1
Figure 1. UC-961 does not cross-react with normal adult human tissues
UC-961 was applied to full tissue lists of human tissues from three separate donors, supplemented with a positive control specimen (pancreatic carcinoma). This was conducted in compliance with GLP regulations. A) The UC-961 staining resulted in and strong (Grade-3) positive-staining intensity on ROR1+ pancreatic tumor cells. B) There was no tissue cross-reactivity at the high concentration on any of the normal human tissues. Representative photomicrographs are shown.
Figure 1
Figure 1. UC-961 does not cross-react with normal adult human tissues
UC-961 was applied to full tissue lists of human tissues from three separate donors, supplemented with a positive control specimen (pancreatic carcinoma). This was conducted in compliance with GLP regulations. A) The UC-961 staining resulted in and strong (Grade-3) positive-staining intensity on ROR1+ pancreatic tumor cells. B) There was no tissue cross-reactivity at the high concentration on any of the normal human tissues. Representative photomicrographs are shown.
See this image and copyright information in PMC

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