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Editorial
. 2015 Aug 7;6(22):18742-3.
doi: 10.18632/oncotarget.5113.

A bacterial toxin that cleaves Ras oncoprotein

Marco Biancucci  1 , Karla J F Satchell  1
Affiliations
Editorial

A bacterial toxin that cleaves Ras oncoprotein

Marco Biancucci et al. Oncotarget. .
No abstract available

Keywords: Chromosome Section; MARTX toxin; RRSP; Ras; bacterial toxin endopeptidase.

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Figures

Figure 1
Figure 1. Schematic representation of Ras activation and its downstream signaling
Dimerization of EGFR activates Son of Sevenless (SOS), a Ras GEF. SOS exchanges GDP with GTP in Ras nucleotide binding site. Ras-GTP binds to RAF, inducing autophosphorylation and dimerization of RAF and subsequently activating downstream protein kinases MEK and ERK. Processing of Ras and Rap1 by RRSP blocks the phosphorylation cascade, inhibiting cell proliferation, survival and differentiation.
See this image and copyright information in PMC

Comment on

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