Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2015:2015:931420.
doi: 10.1155/2015/931420. Epub 2015 Aug 2.

Cell Therapy in Patients with Critical Limb Ischemia

Rita Compagna  1 , Bruno Amato  2 , Salvatore Massa  3 , Maurizio Amato  3 , Raffaele Grande  4 , Lucia Butrico  4 , Stefano de Franciscis  5 , Raffaele Serra  5
Affiliations
Review

Cell Therapy in Patients with Critical Limb Ischemia

Rita Compagna et al. Stem Cells Int. 2015.

Abstract

Critical limb ischemia (CLI) represents the most advanced stage of peripheral arterial obstructive disease (PAOD) with a severe obstruction of the arteries which markedly reduces blood flow to the extremities and has progressed to the point of severe rest pain and/or even tissue loss. Recent therapeutic strategies have focused on restoring this balance in favor of tissue survival using exogenous molecular and cellular agents to promote regeneration of the vasculature. These are based on stimulation of angiogenesis by extracellular and cellular components. This review article carries out a systematic analysis of the most recent scientific literature on the application of stem cells in patients with CLI. The results obtained from the detailed analysis of the recent literature data have confirmed the beneficial role of cell therapy in reducing the rate of major amputations in patients with CLI and improving their quality of life.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Flow of papers identified from search strategy.
See this image and copyright information in PMC

References

    1. Novo S., Coppola G., Milio G. Critical limb ischemia: definition and natural history. Current Drug Targets—Cardiovascular and Haematological Disorders. 2004;4(3):219–225. doi: 10.2174/1568006043335989. - DOI - PubMed
    1. Norgren L., Hiatt W. R., Bell K., et al. Inter-society consensus for the management of peripheral arterial disease (TASC II) European Journal of Vascular and Endovascular Surgery. 2007;33(1):S1–S75. doi: 10.1016/j.ejvs.2006.09.024. - DOI - PubMed
    1. Simons J. P., Goodney P. P., Nolan B. W., Cronenwett J. L., Messina L. M., Schanzer A. Failure to achieve clinical improvement despite graft patency in patients undergoing infrainguinal lower extremity bypass for critical limb ischemia. Journal of Vascular Surgery. 2010;51(6):1419–1424. doi: 10.1016/j.jvs.2010.01.083. - DOI - PMC - PubMed
    1. Libby P. Inflammation in atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology. 2012;32(9):2045–2051. doi: 10.1161/atvbaha.108.179705. - DOI - PMC - PubMed
    1. Hioki H., Miyashita Y., Miura T., et al. Prognostic improvement by multidisciplinary therapy in patients with critical limb ischemia. Angiology. 2014 doi: 10.1177/0003319714523113. - DOI - PubMed

LinkOut - more resources