Uric acid correlates to oxidation and inflammation in opposite directions in women

Abstract

Objective: To evaluate the association of uric acid (UA) levels with a panel of markers of oxidative stress and inflammation.

Methods: Plasma UA levels, along with a panel of oxidative stress and inflammatory markers, were measured in 755 Chinese women.

Results: Plasma UA levels were inversely associated with urinary levels of the oxidative stress marker F2-isoprostanes and positively correlated to levels of inflammatory markers, such as C-reactive protein and some proinflammatory cytokines (tumor necrosis factor-α and interleukin-6) in blood as well as prostaglandin E2 metabolites in urine.

Conclusions: Plasma UA levels correlate to oxidation and inflammation biomarkers in opposite directions in women.

Keywords: Biomarker; inflammation; oxidative stress; uric acid.

Figure 1

Smoothed plot of logarithmically transformed concentrations of oxidative stress and inflammatory markers according to plasma UA levels. The value of the studied markers at the median level of the first quartile of UA was treated as the reference point. The difference in log-transformed concentrations of the markers by UA levels were estimated by restricted cubic-spline linear regression analyses with knots placed at the 5^th (3.7 mg/dL), 50^th (4.9 mg/dL), and 95^th (7.8 mg/dL) percentiles of UA levels after adjustment for age and assay batch. Point estimates are indicated by a solid line and 95% CIs by dashed lines. CRP: C-reactive protein; F₂-IsoPs: 15-F_2t-isoprostanes; TNF-α: tumor necrosis factor α.

Figure 1

Smoothed plot of logarithmically transformed concentrations of oxidative stress and inflammatory markers according to plasma UA levels. The value of the studied markers at the median level of the first quartile of UA was treated as the reference point. The difference in log-transformed concentrations of the markers by UA levels were estimated by restricted cubic-spline linear regression analyses with knots placed at the 5^th (3.7 mg/dL), 50^th (4.9 mg/dL), and 95^th (7.8 mg/dL) percentiles of UA levels after adjustment for age and assay batch. Point estimates are indicated by a solid line and 95% CIs by dashed lines. CRP: C-reactive protein; F₂-IsoPs: 15-F_2t-isoprostanes; TNF-α: tumor necrosis factor α.

Figure 1

Smoothed plot of logarithmically transformed concentrations of oxidative stress and inflammatory markers according to plasma UA levels. The value of the studied markers at the median level of the first quartile of UA was treated as the reference point. The difference in log-transformed concentrations of the markers by UA levels were estimated by restricted cubic-spline linear regression analyses with knots placed at the 5^th (3.7 mg/dL), 50^th (4.9 mg/dL), and 95^th (7.8 mg/dL) percentiles of UA levels after adjustment for age and assay batch. Point estimates are indicated by a solid line and 95% CIs by dashed lines. CRP: C-reactive protein; F₂-IsoPs: 15-F_2t-isoprostanes; TNF-α: tumor necrosis factor α.