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Review
. 2015:41:66-73.
doi: 10.1159/000381164. Epub 2015 Jul 17.

Operationalizing Frailty Using the Frailty Phenotype and Deficit Accumulation Approaches

Olga Theou  1 , Jeremy Walston, Kenneth Rockwood
Affiliations
Review

Operationalizing Frailty Using the Frailty Phenotype and Deficit Accumulation Approaches

Olga Theou et al. Interdiscip Top Gerontol Geriatr. 2015.

Abstract

In both demographic and clinical studies, frailty is understood as a multidimensional state of increased vulnerability compared with the status of others of the same age. Of the many theoretical definitions of frailty, two are commonly employed: the physical frailty/phenotypic approach and the deficit accumulation approach. The purpose of this chapter is to discuss how frailty is conceptualized and operationalized based on these two approaches.

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Figures

Fig. 1
Fig. 1
The cycle of frailty.
See this image and copyright information in PMC

References

    1. Vaupel JW, Manton KG, Stallard E. The impact of heterogeneity in individual frailty on the dynamics of mortality. Demography. 1979;16:439–454. - PubMed
    1. Sternberg SA, Wershof Schwartz A, Karunananthan S, et al. The identification of frailty: a systematic literature review. J Am Geriatr Soc. 2011;59:2129–2138. - PubMed
    1. Pijpers E, Ferreiraa I, Stehouwera C, et al. The frailty dilemma: review of the predictive accuracy of major frailty scores. Eur J Intern Med. 2012;23:118–123. - PubMed
    1. Mitnitski A, Song X, Rockwood K. Assessing biological aging: the origin of deficit accumulation. Biogerontology. 2013;14:709–717. - PMC - PubMed
    1. Little JDC. Little’s law as viewed on its 50th anniversary. Operations Research. 2011;59:536–549.