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. 2015 Oct 12;16(15):2137-9.
doi: 10.1002/cbic.201500379. Epub 2015 Sep 3.

How Many Biochemistries Are Available To Build a Cell?

Carlos G Acevedo-Rocha  1   2 , Dirk Schulze-Makuch  3   4   5
Affiliations

How Many Biochemistries Are Available To Build a Cell?

Carlos G Acevedo-Rocha et al. Chembiochem. .

Abstract

The manual experimental evolution of the bacterium Escherichia coli allowed the design of a noncanonical genetic code in which complete replacement of the endogenous building block tryptophan (left) by an exogenous one based on a thienylpyrrole (right) was achieved after 506 days of continuous culturing.

Keywords: biocatalysis; chemical synthetic biology; continuous evolution; genetic code engineering; unnatural amino acids.

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