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Editorial
. 2015 Aug 14;6(23):19342-3.
doi: 10.18632/oncotarget.4938.

Post-translesion synthesis repair

Jacob G Jansen  1 , Anastasia Tsaalbi-Shtylik  1 , Niels de Wind  1
Affiliations
Editorial

Post-translesion synthesis repair

Jacob G Jansen et al. Oncotarget. .
No abstract available

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Figures

Figure 1
Figure 1. Model for the induction of DDR and the suppression of mutations by post-TLS repair
Error-prone TLS at distorting nucleotide lesions (red+orange tract in panel A) prevents the induction of DSBs and of DDR, at the price of incorrect incorporations that result in mutations during the S phase of the next cell cycle. Post TLS repair (panel B) excises the TLS error. The resulting ssDNA tract induces DDR. We hypothesise that, during the next S phase, the gapped template can collapse to a DSB, mediating a delayed apoptotic response. Error-free gap filling by TLS (panel C, orange tract) prevents the induction of a nucleotide substitution.
See this image and copyright information in PMC

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