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Editorial
. 2015 Aug 14;6(23):19362-3.
doi: 10.18632/oncotarget.5125.

SRSF1 inhibition of HIV-1 gene expression

Sean Paz  1 , Massimo Caputi  1
Affiliations
Editorial

SRSF1 inhibition of HIV-1 gene expression

Sean Paz et al. Oncotarget. .
No abstract available

Keywords: HIV-1; Immune response; Immunity; Immunology and Microbiology Section; SRSF1.

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Figures

Figure 1
Figure 1. SRSF1 inhibits HIV replication
Several SRSF1 binding sites have been experimentally characterized (red lines) and predicted (black lines) within the HIV-1 transcript. SRSF1 binding onto the viral transcript can impact both, transcription and splicing. Our data [2, 5] indicate that at a low SRSF1 concentration the viral protein Tat binds TAR and increases viral transcription by modifying the composition of the transcription complex and inducing phosphorylation of RNAPII. At high concentrations SRSF1 competes with Tat for binding onto TAR, which results in a reduction of viral transcription. Similarly, splicing of the viral mRNA is modulated by cellular factors that bind sequences in proximity of the splice sites and regulate the recruitment of spliceosomal components. SRSF1 can compete with such regulatory factors by binding onto overlapping sequences within the target transcript.
See this image and copyright information in PMC

References

    1. Houzet L, et al. Exp Biol Med (Maywood) 2011;236:962–967. - PMC - PubMed
    1. Paz S, et al. Nucleic acids research. 2014;42:13812–13823. - PMC - PubMed
    1. Zhong XY, et al. Molecular cell. 2009;35:1–10. - PMC - PubMed
    1. Karn J, et al. Cold Spring Harbor perspectives in medicine. 2012;2:a006916. - PMC - PubMed
    1. Paz S, et al. Journal of virology. 2015

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