Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2015 Aug 25:2015:bcr2015210061.
doi: 10.1136/bcr-2015-210061.

Chronic recurrent multifocal osteomyelitis: a rare skeletal disorder

Deniz Aygun  1 , Kenan Barut  2 , Yildiz Camcioglu  1 , Ozgur Kasapcopur  2
Affiliations
Case Reports

Chronic recurrent multifocal osteomyelitis: a rare skeletal disorder

Deniz Aygun et al. BMJ Case Rep. .

Abstract

Chronic recurrent multifocal osteomyelitis (CRMO) is a rare non-infectious inflammatory bone disease of unknown aetiology. CRMO mainly affects the metaphyses of long bones and spine in children and young adolescents. It presents with recurrent episodes of bone pain and fever, resembling bacterial osteomyelitis, but cultures of lesions are sterile and it is unresponsive to antibiotic therapy. We report a case of a 3-year-old boy diagnosed with CRMO, who was initially treated for bacterial osteomyelitis, and received prolonged antibiotic therapy for chronic pain, and swelling of mandible and ulna. CRMO should be kept in mind in the differential diagnosis of chronic bone pain and osteomyelitis unresponsive to antibiotic treatment.

PubMed Disclaimer

Figures

Figure 1
Figure 1
(A) and (B) Soft tissue swelling with periosteal thickening on X-ray and MRI.
Figure 2
Figure 2
Lytic lesions with periosteal reaction, suggesting malignancy.
See this image and copyright information in PMC

References

    1. Giedion A, Holthusen W, Masel LF et al. . Subacute and chronic “symmetrical” osteomyelitis. Ann Radiol 1972;15:329–42. - PubMed
    1. Falip C, Alison M, Boutry N et al. . Chronic recurrent multifocal osteomyelitis [CRMO]. A longitudinal case series review. Pediatr Radiol 2013;43:355–75. 10.1007/s00247-012-2544-6 - DOI - PubMed
    1. Catalano-Pons C, Comte A, Wipff J et al. . Clinical outcome in children with chronic recurrent multifocal osteo-myelitis. Rheumatology 2008;47:1397–9. 10.1093/rheumatology/ken249 - DOI - PubMed
    1. Brown T, Wilkinson RH. Chronic recurrent multifocal osteomyelitis. Radiology 1988;166:493–6. 10.1148/radiology.166.2.3336727 - DOI - PubMed
    1. Wipff J, Costantino F, Lemelle I et al. . A large national cohort of French patients with chronic recurrent multifocal osteitis. Arthritis Rheumatol 2015;67:1128–37. 10.1002/art.39013 - DOI - PubMed

Publication types

Substances

Supplementary concepts