Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Nov;167A(11):2610-7.
doi: 10.1002/ajmg.a.37246. Epub 2015 Aug 26.

Differences in mortality and morbidity according to gestational ages and birth weights in infants with trisomy 18

Ken Imai  1 , Atsushi Uchiyama  1 , Tomoka Okamura  1 , Mako Ago  1 , Hideyo Suenaga  1 , Eri Sugita  1 , Hideko Ono  1 , Kyoko Shuri  1 , Kenichi Masumoto  1 , Satsuki Totsu  1 , Hidehiko Nakanishi  1 , Satoshi Kusuda  1
Affiliations

Differences in mortality and morbidity according to gestational ages and birth weights in infants with trisomy 18

Ken Imai et al. Am J Med Genet A. 2015 Nov.

Abstract

The aim of this study was to clarify the effects of gestational age and birth weight on outcomes of the infants. Medical records of 36 infants with trisomy 18 admitted to Tokyo Women's Medical University Hospital from 1991 to 2012 were reviewed retrospectively. We compared clinical characteristics between term infants (n = 15) and preterm infants (n = 21). There were one very-low-birth-weight (VLBW) term infant (5%) and 12 VLBW preterm infants (80%). Although there were no significant differences in clinical characteristics and provided management between the two groups, none of the preterm infants achieved survival to discharge. On the other hand, 6 of 21 term infants (29%) achieved survival to discharge (P < 0.05). Similar results were obtained for comparisons between the VLBW infants and non-VLBW infants. Multiple logistic regression analysis revealed that shorter gestational age had a more negative impact than lower birth weight to survival to discharge in infants with trisomy 18. In both preterm and term groups, the infants who died before 30 days commonly died of respiratory failure or apnea. Whereas, the infants who survived more than 30 days mostly died of heart failure.

Keywords: mortality; preterm; prognosis; trisomy 18; very-low-birth-weight infant.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Flowchart of study patients and main outcomes between preterm and term groups. VLBW, very low birth weight.
Figure 2
Figure 2
Kaplan–Meier survival curves for patients with trisomy 18 in preterm (red line) and term (blue line) groups. The survival time of the preterm group was significantly shorter than that of the term group (P < 0.05).
See this image and copyright information in PMC

References

    1. Boghossian NS, Hansen NI, Bell EF, Stoll BJ, Murray JC, Carey JC, Adams‐Chapman I, Shankaran S, Walsh MC, Laptook AR, Faix RG, Newman NS, Hale EC, Das A, Wilson LD, Hensman AM, Grisby C, Collins MV, Vasil DM, Finkle J, Maffett D, Ball MB, Lacy CB, Bara R, Higgins RD. 2014. Mortality and morbidity of VLBW infants with trisomy 13 or trisomy 18. Pediatrics 133:226–236. - PMC - PubMed
    1. Brewer CM, Holloway SH, Stone DH, Carothers AD, FitzPatrick DR. 2002. Survival in trisomy 13 and trisomy 18 cases ascertained from population based registers. J Med Genet 39:e54. - PMC - PubMed
    1. Carey JC. 2012. Perspectives on the care and management of infants with trisomy 18 and trisomy 13: Striving for balance. Curr Opin Pediatr 24:672–678. - PubMed
    1. Carter P, Pearn J, Bell J, Martin N, Anderson N. 1985. Survival in trisomy 18. Clin Genet 27:59–61. - PubMed
    1. Edwards JH, Harnden DG, Cameron AH, Cross BM, Wolff OH. 1960. A new trisomic syndrome. Lancet 1:787. - PubMed