Optogenetics: 10 years after ChR2 in neurons--views from the community

Antoine Adamantidis¹, Silvia Arber², Jaideep S Bains³, Ernst Bamberg⁴, Antonello Bonci⁵, György Buzsáki⁶, Jessica A Cardin⁷, Rui M Costa⁸, Yang Dan⁹, Yukiko Goda¹⁰, Ann M Graybiel¹¹, Michael Häusser¹², Peter Hegemann¹³, John R Huguenard¹⁴, Thomas R Insel¹⁵, Patricia H Janak¹⁶, Daniel Johnston¹⁷, Sheena A Josselyn¹⁸, Christof Koch¹⁹, Anatol C Kreitzer²⁰, Christian Lüscher²¹, Robert C Malenka²², Gero Miesenböck²³, Georg Nagel²⁴, Botond Roska²⁵, Mark J Schnitzer²⁶, Krishna V Shenoy²⁷, Ivan Soltesz²⁸, Scott M Sternson²⁹, Richard W Tsien³⁰, Roger Y Tsien³¹, Gina G Turrigiano³², Kay M Tye³³, Rachel I Wilson³⁴

Affiliations

¹ Department of Psychiatry, Douglas Mental Health University Institute, McGill University, Montréal, Canada, and the Department of Neurology, Inselspital University Hospital, University of Bern, Bern, Switzerland.
² Biozentrum, Department of Cell Biology, University of Basel, Basel, Switzerland, and the Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland.
³ Department of Physiology and Pharmacology, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada.
⁴ Max Planck Institute of Biophysics, Frankfurt am Main, Germany.
⁵ Intramural Research Program, Synaptic Plasticity Section, National Institute on Drug Abuse, Baltimore, Maryland, USA, the Solomon H. Snyder Neuroscience Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA, and in the Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
⁶ The Neuroscience Institute, School of Medicine and Center for Neural Science, New York University, New York, New York, USA.
⁷ Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut, USA, and at the Kavli Institute of Neuroscience, Yale University, New Haven, Connecticut, USA.
⁸ Champalimaud Neuroscience Programme, Champalimaud Center for the Unknown, Lisbon, Portugal.
⁹ Division of Neurobiology, Department of Molecular and Cell Biology, Helen Wills Neuroscience Institute, Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, California, USA.
¹⁰ RIKEN Brain Science Institute, Wako-shi, Saitama, Japan.
¹¹ McGovern Institute for Brain Research and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
¹² Wolfson Institute for Biomedical Research and Department of Neuroscience, Physiology and Pharmacology, University College London, London, United Kingdom.
¹³ Institut für Biologie/Experimentelle Biophysik, Humboldt Universität zu Berlin, Berlin, Germany.
¹⁴ Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA.
¹⁵ National Institute of Mental Health, Bethesda, Maryland, USA.
¹⁶ Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, Maryland, USA, and the Department of Neuroscience, Johns Hopkins University, Baltimore, Maryland, USA.
¹⁷ Department of Neuroscience and Center for Learning and Memory, University of Texas at Austin, Austin, Texas, USA.
¹⁸ Program in Neurosciences and Mental Health, The Hospital for Sick Children, Peter Gilgan Centre for Research and Learning, Toronto, Ontario, Canada, and the Departments of Psychology and Physiology and Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.
¹⁹ Allen Institute for Brain Science, Seattle, Washington, USA.
²⁰ The Gladstone Institutes, San Francisco, California, USA, and the Departments of Neurology and Physiology, University of California, San Francisco, San Francisco, California, USA.
²¹ Department of Basic Neurosciences, University of Geneva, Geneva, Switzerland, and the Service of Neurology, Department of Clinical Neurosciences, University Hospital of Geneva, Geneva, Switzerland.
²² Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, Stanford, California, USA.
²³ Centre for Neural Circuits and Behaviour, University of Oxford, Tinsley Building, Mansfield Road, Oxford, UK.
²⁴ Institute for Molecular Plant Physiology and Biophysics, Biocenter, Julius-Maximilians-University of Würzburg, Würzburg, Germany.
²⁵ Neural Circuit Laboratories, Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland. Department of Ophthalmology, University of Basel, Basel, Switzerland.
²⁶ James H. Clark Center for Biomedical Engineering and Sciences, Stanford University, Stanford, California, USA, the Howard Hughes Medical Institute, Stanford University, Stanford, California, USA, and the CNC Program, Stanford University, Stanford, California, USA.
²⁷ Departments of Electrical Engineering, Bioengineering and Neurobiology, the Neurosciences and Bio-X Programs, the Stanford Neurosciences Institute and the Howard Hughes Medical Institute, Stanford University, Stanford, California, USA.
²⁸ Department of Neurosurgery, Stanford University, Stanford, California, USA.
²⁹ Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia, USA.
³⁰ Department of Neuroscience and Physiology, Neuroscience Institute, New York University Langone Medical Center, New York, New York, USA.
³¹ Department of Pharmacology, Howard Hughes Medical Institute, Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California, USA.
³² Department of Biology and Center for Behavioral Genomics, Brandeis University, Waltham, Massachusetts, USA.
³³ The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
³⁴ Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, USA.

PMID: 26308981
DOI: 10.1038/nn.4106

Free article

Review

Optogenetics: 10 years after ChR2 in neurons--views from the community

Antoine Adamantidis et al. Nat Neurosci. 2015 Sep.

Free article

. 2015 Sep;18(9):1202-12.

doi: 10.1038/nn.4106.

Authors

Affiliations

¹ Department of Psychiatry, Douglas Mental Health University Institute, McGill University, Montréal, Canada, and the Department of Neurology, Inselspital University Hospital, University of Bern, Bern, Switzerland.
² Biozentrum, Department of Cell Biology, University of Basel, Basel, Switzerland, and the Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland.
³ Department of Physiology and Pharmacology, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada.
⁴ Max Planck Institute of Biophysics, Frankfurt am Main, Germany.
⁵ Intramural Research Program, Synaptic Plasticity Section, National Institute on Drug Abuse, Baltimore, Maryland, USA, the Solomon H. Snyder Neuroscience Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA, and in the Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
⁶ The Neuroscience Institute, School of Medicine and Center for Neural Science, New York University, New York, New York, USA.
⁷ Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut, USA, and at the Kavli Institute of Neuroscience, Yale University, New Haven, Connecticut, USA.
⁸ Champalimaud Neuroscience Programme, Champalimaud Center for the Unknown, Lisbon, Portugal.
⁹ Division of Neurobiology, Department of Molecular and Cell Biology, Helen Wills Neuroscience Institute, Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, California, USA.
¹⁰ RIKEN Brain Science Institute, Wako-shi, Saitama, Japan.
¹¹ McGovern Institute for Brain Research and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
¹² Wolfson Institute for Biomedical Research and Department of Neuroscience, Physiology and Pharmacology, University College London, London, United Kingdom.
¹³ Institut für Biologie/Experimentelle Biophysik, Humboldt Universität zu Berlin, Berlin, Germany.
¹⁴ Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA.
¹⁵ National Institute of Mental Health, Bethesda, Maryland, USA.
¹⁶ Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, Maryland, USA, and the Department of Neuroscience, Johns Hopkins University, Baltimore, Maryland, USA.
¹⁷ Department of Neuroscience and Center for Learning and Memory, University of Texas at Austin, Austin, Texas, USA.
¹⁸ Program in Neurosciences and Mental Health, The Hospital for Sick Children, Peter Gilgan Centre for Research and Learning, Toronto, Ontario, Canada, and the Departments of Psychology and Physiology and Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.
¹⁹ Allen Institute for Brain Science, Seattle, Washington, USA.
²⁰ The Gladstone Institutes, San Francisco, California, USA, and the Departments of Neurology and Physiology, University of California, San Francisco, San Francisco, California, USA.
²¹ Department of Basic Neurosciences, University of Geneva, Geneva, Switzerland, and the Service of Neurology, Department of Clinical Neurosciences, University Hospital of Geneva, Geneva, Switzerland.
²² Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, Stanford, California, USA.
²³ Centre for Neural Circuits and Behaviour, University of Oxford, Tinsley Building, Mansfield Road, Oxford, UK.
²⁴ Institute for Molecular Plant Physiology and Biophysics, Biocenter, Julius-Maximilians-University of Würzburg, Würzburg, Germany.
²⁵ Neural Circuit Laboratories, Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland. Department of Ophthalmology, University of Basel, Basel, Switzerland.
²⁶ James H. Clark Center for Biomedical Engineering and Sciences, Stanford University, Stanford, California, USA, the Howard Hughes Medical Institute, Stanford University, Stanford, California, USA, and the CNC Program, Stanford University, Stanford, California, USA.
²⁷ Departments of Electrical Engineering, Bioengineering and Neurobiology, the Neurosciences and Bio-X Programs, the Stanford Neurosciences Institute and the Howard Hughes Medical Institute, Stanford University, Stanford, California, USA.
²⁸ Department of Neurosurgery, Stanford University, Stanford, California, USA.
²⁹ Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia, USA.
³⁰ Department of Neuroscience and Physiology, Neuroscience Institute, New York University Langone Medical Center, New York, New York, USA.
³¹ Department of Pharmacology, Howard Hughes Medical Institute, Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California, USA.
³² Department of Biology and Center for Behavioral Genomics, Brandeis University, Waltham, Massachusetts, USA.
³³ The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
³⁴ Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, USA.

PMID: 26308981
DOI: 10.1038/nn.4106

No abstract available

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References

1. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):13940-5 - PubMed
1. Curr Biol. 2005 Dec 20;15(24):2279-84 - PubMed
1. Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):1352-7 - PubMed
1. Neuron. 2002 Jan 3;33(1):15-22 - PubMed
1. J Neurosci. 2006 Oct 11;26(41):10380-6 - PubMed

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Optogenetics: 10 years after ChR2 in neurons--views from the community

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Optogenetics: 10 years after ChR2 in neurons--views from the community

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