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. 2015 Jun 15;8(6):9355-61.
eCollection 2015.

Association between TCF7L2 polymorphisms and breast cancer susceptibility: a meta-analysis

Feng Wang  1 , Lixin Jiang  2 , Jianlin Li  3 , Xiao Yu  4 , Mingchuan Li  5 , Guochang Wu  2 , Zhenyu Yu  5 , Kai Zhou  2 , Haidi Chu  2 , Huiyuan Zhai  2
Affiliations

Association between TCF7L2 polymorphisms and breast cancer susceptibility: a meta-analysis

Feng Wang et al. Int J Clin Exp Med. .

Abstract

Aim: Our aim was to investigate the relationship between transcription factor 7-like 2 (TCF7L2) polymorphisms and breast cancer susceptibility.

Methods: PubMed, Embase and CNKI databases were used to search the related studies investigating the correlation between TCF7L2 polymorphisms and breast cancer susceptibility. Pooled ORs and 95% CIs, based on five genetic models, were applied to estimate the association betweenTCF7L2 polymorphisms and breast cancer. A fixed-effect model or a random-effect model was applied according to the between-study heterogeneity.

Results: We analyzed six single nucleotide polymorphisms (SNPs) in TCF7L2 gene, namely rs12255372, rs7903146, rs7900150, rs3750805, rs1225404 and rs7003146. The increased risk of breast cancer was associated with TCF7L2 polymorphisms (22 vs. 11: OR=1.16, 95% CI=1.02-1.32; 22+12 vs. 11: OR=1.06, 95% CI=1.02-1.10; 22 vs. 11+12: OR=1.15, 95% CI=1.04-1.27; 2 vs. 1: OR=1.07, 95% CI=1.02-1.13; 12 vs. 11: OR=1.05, 95% CI=1.01-1.09). Among the locus, rs7903146 polymorphism was significantly associated with the risk for breast cancer under five genetic models (TT vs. CC: OR=1.29, 95% CI=1.08-1.53; TT+CT vs. CC: OR=1.09, 95% CI=1.01-1.18; TT vs. CC+CT: OR=1.24, 95% CI=1.05-1.48; T vs. C: OR=1.11, 95% CI=1.04-1.19; CT vs. CC: OR=1.08, 95% CI=1.00-1.17). Additionally, rs7900150 also showed effects on the susceptibility of breast cancer (TT vs. AA: OR=1.22, 95% CI=1.07-1.39; TT+AT vs. AA: OR=1.06, 95% CI=1.00-1.14; TT vs. AA+AT: OR=1.21, 95% CI=1.07-1.37; T vs. A: OR=1.09, 95% CI=1.02-1.15; AT vs. AA: OR=1.04, 95% CI=1.01-1.33). Meanwhile, we found that rs3750805 polymorphism could increased the risk for breast cancer (TT+AT vs. AA: OR=1.12, 95% CI=1.01-1.24).

Conclusion: Our meta-analysis demonstrates that TCF7L2 polymorphisms may increase the risk for breast cancer.

Keywords: TCF7L2; breast cancer; polymorphisms.

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Figures

Figure 1
Figure 1
Flow diagram of included studies in the meta-analysis.
Figure 2
Figure 2
Forest plot of risk of breast cancer associated with TCF7L2 polymorphisms.
Figure 3
Figure 3
Begg’s funnel plot of publication bias test.
See this image and copyright information in PMC

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