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Comment
. 2015 Sep 8;112(36):11150-1.
doi: 10.1073/pnas.1514284112. Epub 2015 Aug 26.

The growing importance of mitochondrial calcium in health and disease

Liron Boyman  1 , George S B Williams  1 , W J Lederer  2
Affiliations
Comment

The growing importance of mitochondrial calcium in health and disease

Liron Boyman et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Critical observations related to mitochondrial dynamics and the etiology of HF. (A) Schematic diagram showing the spatial distribution of mitochondrial Ca2+ signaling components in heart. The ends of each intermyofibrillar mitochondrion are in close proximity (∼100 nm) to the Ca2+ release units (CRUs) that are located between the transverse-tubule (TT) and junctional SR (jsr) membranes [also see Williams et al. (24)]. (B) Venn diagram highlighting key differences and similarities in WT mice and mice with leaky RyRs (S2808D) and how these properties develop during HF. Observations related to the critical questions (outlined here) provoked by Santulli et al. (1) are bolded.
See this image and copyright information in PMC

Comment on

References

    1. Santulli G, Xie W, Reiken SR, Marks AR. Mitochondrial calcium overload is a key determinant in heart failure. Proc Natl Acad Sci USA. 2015;112:11389–11394. - PMC - PubMed
    1. Williams GS, Boyman L, Lederer WJ. Mitochondrial calcium and the regulation of metabolism in the heart. J Mol Cell Cardiol. 2015;78:35–45. - PMC - PubMed
    1. Glancy B, Balaban RS. Role of mitochondrial Ca2+ in the regulation of cellular energetics. Biochemistry. 2012;51(14):2959–2973. - PMC - PubMed
    1. Boyman L, et al. Calcium movement in cardiac mitochondria. Biophys J. 2014;107(6):1289–1301. - PMC - PubMed
    1. Murphy MP. How mitochondria produce reactive oxygen species. Biochem J. 2009;417(1):1–13. - PMC - PubMed

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