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Case Reports
. 2015 May-Jun;90(3 Suppl 1):32-5.
doi: 10.1590/abd1806-4841.20153782.

Atypical presentation of histoplasmosis in an immunocompromised patient

Talita voss Gonzalez  1 , Sandra Lopes Mattos e Dinato  2 , Angelo Sementilli  2 , Ney Romiti  2 , Patrícia Mara Beltrame  3 , Ana Paula Rocha Veiga  2
Affiliations
Case Reports

Atypical presentation of histoplasmosis in an immunocompromised patient

Talita voss Gonzalez et al. An Bras Dermatol. 2015 May-Jun.

Abstract

We present a case of disseminated cutaneous histoplasmosis in a male patient, rural worker, HIV positive for 20 years, with a history of irregular use of antiretroviral therapy, T cell counts below 50 cells/mm3 and with good response to treatment with Itraconazole. We highlight importance of skin lesions in clarifying early diagnosis, since this co-infection often leads patients to death.

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Conflict of interest statement

Conflict of Interest: None.

Figures

FIGURE 1
FIGURE 1
Pili torti. Polarized light microscopy, 10x magnification: Hair twisted about its longitudinal axis
FIGURE 2
FIGURE 2
100X HE: Skin sample containing histiocytic infi ltration in the dermis, which show punctate structures in the cytoplasm
FIGURE 3
FIGURE 3
Groccot 400X: In the silver staining it’s possible to note oval and uniform intracellular and grouped structures compatible with Histoplasma
FIGURE 4
FIGURE 4
Culture - Microscopic examination: presence of tuberculate microconidia and macroconidia
FIGURE 5
FIGURE 5
Culture - macroscopic examination: presence of white cotton-wool spots nies
FIGURE 6
FIGURE 6
Culture - macroscopic examination: presence of white cotton-wool spots colonies
See this image and copyright information in PMC

References

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