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Case Reports
. 2015 May-Jun;90(3 Suppl 1):143-6.
doi: 10.1590/abd1806-4841.20153651.

Pre-tibial myxedema: treatment with intralesional corticosteroid

Luana Oliveira Ramos  1 , Paloma Corrêa Mattos  1 , Giuseppe Lemos Pertoti de Figueredo  1 , Alef Alioscha Andrade Maia  1 , Sandra Adolfina Reys Romero  1
Affiliations
Case Reports

Pre-tibial myxedema: treatment with intralesional corticosteroid

Luana Oliveira Ramos et al. An Bras Dermatol. 2015 May-Jun.

Abstract

The pretibial myxedema is a manifestation of Graves' disease characterized by accumulation of glycosaminoglycans in the reticular dermis. The dermopathy is self-limiting but in some cases may cause cosmetic and functional damage. Conventional treatment is use of topical steroids under occlusive dressing, however the intralesional application has shown good results. We present a case of pretibial myxedema treated with single injection of intralesional corticosteroid.

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Conflict of interest statement

Conflict of Interest: None.

Figures

FIGURE 1
FIGURE 1
Plaque with “orange peel” surface on anterior face of right leg
FIGURE 2
FIGURE 2
Exophthalmos
FIGURE 3
FIGURE 3
Histopathological examination (H&E, x40) showing epidermis and papillary dermis without abnormalities. Accumulation of mucin in reticular dermis
FIGURE 4
FIGURE 4
Histopathological examination (H&E, x100). Accumulation of mucin in reticular dermis causing separation of collagen bundles
FIGURE 5
FIGURE 5
Response after 1 application of intralesional corticosteroid
See this image and copyright information in PMC

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