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Case Reports
. 2015 May-Jun;90(3 Suppl 1):200-2.
doi: 10.1590/abd1806-4841.20153762.

Cheilitis granulomatosa associated with lupus erythematosus discoid and treated with methotrexate: report of a case

Gianluca Nazzaro  1 , Simona Muratori  1 , Carlo Giovanni Carrera  1 , Antonella Coggi  1 , Raffaele Gianotti  1
Affiliations
Case Reports

Cheilitis granulomatosa associated with lupus erythematosus discoid and treated with methotrexate: report of a case

Gianluca Nazzaro et al. An Bras Dermatol. 2015 May-Jun.

Abstract

We present the rare case of a 47-year-old patient, suffering from cheilitis granulomatosa and lupus erythematosus discoid: this association is really exceptional because only once reported in English literature. In addition, the treatment of cheilitis granulomatosa is a challenge for the dermatologist: the gold standard, represented by steroids, is in fact designed as a short-time option. Our report confirms the good efficacy of methotrexate as a steroid-sparing agent.

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Conflict of interest statement

Conflicts of Interest: None.

Figures

FIGURE 1
FIGURE 1
Persistent swelling of the upper lip, associated with erythematous-desquamative lesions
FIGURE 2
FIGURE 2
Non necrotizing granulomas in the reticular dermis [H-E 20x]
FIGURE 3
FIGURE 3
Atrophic epidermis with hyperkeratosis and vacuolization of the basal layer. In the dermis, perivascular infiltrate and deposit of mucin among collagen bundles [H-E 10x]
See this image and copyright information in PMC

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References

    1. Miescher G. Über essentielle granulmatöse Makrocheilie (Cheilitis granulomatosa) Dermatologica. 1945;91:57–85.
    1. van der Waal RI.Schulten EA.van de Scheur MR.Wauters IM.Starink TM.van der Waal I Cheilitis granulomatosa. J Eur Acad Dermatol Venereol. 2001;15:519–523. - PubMed
    1. Dupuy A, Cosnes J, Revuz J, Delchier JC, Gendre JP, Cosnes A. Oral Crohn disease. Arch Dermatol. 1999;135:439–442. - PubMed
    1. Kano Y, Shiohara T, Yagita A, Nagashima M. Association between cheilitis ganulomatosa and Crohn's disease. J Am Acad Dermatol. 1993;28:801–801. - PubMed
    1. Bacci C, Valente ML. Successful treatment of cheilitis granulomatosa with intralesional injection of Triamcinolone. J Eur Acad Dermatol Venereol. 2010;24:363–364. - PubMed

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