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Review
. 2015 Oct-Dec;13(4):627-35.
doi: 10.1590/S1679-45082015RW3308. Epub 2015 Aug 21.

An update of neurological manifestations of vasculitides and connective tissue diseases: a literature review

[Article in English, Portuguese]
Anastasia Bougea  1 , Evangelos Anagnostou  1 , Nikolaos Spandideas  1 , Nikolaos Triantafyllou  1 , Evangelia Kararizou  1
Affiliations
Review

An update of neurological manifestations of vasculitides and connective tissue diseases: a literature review

[Article in English, Portuguese]
Anastasia Bougea et al. Einstein (Sao Paulo). 2015 Oct-Dec.

Abstract
in English, Portuguese

Vasculitides comprise a heterogeneous group of autoimmune disorders, occurring as primary or secondary to a broad variety of systemic infectious, malignant or connective tissue diseases. The latter occur more often but their pathogenic mechanisms have not been fully established. Frequent and varied central and peripheral nervous system complications occur in vasculitides and connective tissue diseases. In many cases, the neurological disorders have an atypical clinical course or even an early onset, and the healthcare professionals should be aware of them. The purpose of this brief review was to give an update of the main neurological disorders of common vasculitis and connective tissue diseases, aiming at accurate diagnosis and management, with an emphasis on pathophysiologic mechanisms.

As vasculites são um grupo heterogêneo de doenças autoimunes primárias ou secundárias a uma grande variedade de doenças infecciosas sistêmicas, malignas ou do tecido conjuntivo. Estas últimas são as que ocorrem com mais frequência, porém os mecanismos patogênicos ainda não foram plenamente determinados. Diversas e frequentes complicações do sistema nervoso central e periférico ocorrem nas vasculites e doenças do tecido conjuntivo. Em muitos casos, os distúrbios neurológicos têm evolução clínica atípica ou mesmo início precoce, ao que todos os profissionais de saúde devem estar cientes. O objetivo desta breve revisão foi atualizar os principais distúrbios neurológicos da vasculite comum e das doenças do tecido conjuntivo, visando ao diagnóstico e ao tratamento corretos, com ênfase nos mecanismos fisiopatológicos.

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