. 2015 Sep 1;113(5):716-21.

doi: 10.1038/bjc.2015.279. Epub 2015 Aug 27.

Brain metastases in gastro-oesophageal adenocarcinoma: insights into the role of the human epidermal growth factor receptor 2 (HER2)

J Feilchenfeldt^{1

2}, Z Varga³, M Siano⁴, H I Grabsch⁵, U Held⁶, B Schuknecht⁷, A Trip⁸, T Hamaguchi⁹, P Gut¹⁰, O Balague¹¹, K Khanfir¹², J Diebold¹³, W Jochum¹⁴, H Shoji⁹, R Kushima¹⁵, D Wagner¹⁶, Y Shimada⁹, A Cats¹⁷, A Knuth^{2

18}, H Moch³, S Aebi¹⁹, S Hofer^{18

19}

Affiliations

¹ Service d'oncologie médical, Hôpital du Valais, Sion 1951, Switzerland.
² NCCCR, Hamad Medical Corporation, PO Box 3050, Doha, Qatar.
³ Institute of Surgical Pathology, University Hospital Zurich, Zurich 8091, Switzerland.
⁴ Department of Oncology and Hematology, Kantonsspital St Gallen, St Gallen 9700, Switzerland.
⁵ Department of Pathology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht 6229HX, The Netherlands.
⁶ Horten Center for Patient-Oriented Research and Knowledge Transfer, University of Zurich, Zurich 8091, Switzerland.
⁷ Neuroradiology, MRI Medizinisch Radiologisches Institut, Zurich 8001, Switzerland.
⁸ Department of Radiation Oncology, Netherlands Cancer Institute, Amsterdam 1066, The Netherlands.
⁹ Gastrointestinal Medical Oncology Division, National Cancer Center Hospital Tokyo, Tokyo 104-0045, Japan.
¹⁰ Department of Radiooncology, Luzerner Kantonsspital, Lucerne 6000, Switzerland.
¹¹ Department of Pathology, Netherlands Cancer Institute, Amsterdam 1066, The Netherlands.
¹² Department of Radiooncology, Hôpital du Valais, Sion 1951, Switzerland.
¹³ Institute of Pathology, Luzerner Kantonsspital, Lucerne 6000, Switzerland.
¹⁴ Institute of Pathology, Kantonsspital, St Gallen 9700, Switzerland.
¹⁵ Department of Clinical Laboratory Medicine and Pathology, Shiga University of Medical Science, Seta, Otsu, Shiga 520-2192, Japan.
¹⁶ Department of Oncology, CHUV, Lausanne 1011, Switzerland.
¹⁷ Department of Gastroenterology, Netherlands Cancer Institute, Amsterdam 1066, The Netherlands.
¹⁸ Department of Oncology, University Hospital Zurich, Zurich 8091, Switzerland.
¹⁹ Department of Oncology, Luzerner Kantonsspital, Lucerne 6000, Switzerland.

PMID: 26313663
PMCID: PMC4559836
DOI: 10.1038/bjc.2015.279

Brain metastases in gastro-oesophageal adenocarcinoma: insights into the role of the human epidermal growth factor receptor 2 (HER2)

J Feilchenfeldt et al. Br J Cancer. 2015.

. 2015 Sep 1;113(5):716-21.

doi: 10.1038/bjc.2015.279. Epub 2015 Aug 27.

Authors

Affiliations

¹ Service d'oncologie médical, Hôpital du Valais, Sion 1951, Switzerland.
² NCCCR, Hamad Medical Corporation, PO Box 3050, Doha, Qatar.
³ Institute of Surgical Pathology, University Hospital Zurich, Zurich 8091, Switzerland.
⁴ Department of Oncology and Hematology, Kantonsspital St Gallen, St Gallen 9700, Switzerland.
⁵ Department of Pathology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht 6229HX, The Netherlands.
⁶ Horten Center for Patient-Oriented Research and Knowledge Transfer, University of Zurich, Zurich 8091, Switzerland.
⁷ Neuroradiology, MRI Medizinisch Radiologisches Institut, Zurich 8001, Switzerland.
⁸ Department of Radiation Oncology, Netherlands Cancer Institute, Amsterdam 1066, The Netherlands.
⁹ Gastrointestinal Medical Oncology Division, National Cancer Center Hospital Tokyo, Tokyo 104-0045, Japan.
¹⁰ Department of Radiooncology, Luzerner Kantonsspital, Lucerne 6000, Switzerland.
¹¹ Department of Pathology, Netherlands Cancer Institute, Amsterdam 1066, The Netherlands.
¹² Department of Radiooncology, Hôpital du Valais, Sion 1951, Switzerland.
¹³ Institute of Pathology, Luzerner Kantonsspital, Lucerne 6000, Switzerland.
¹⁴ Institute of Pathology, Kantonsspital, St Gallen 9700, Switzerland.
¹⁵ Department of Clinical Laboratory Medicine and Pathology, Shiga University of Medical Science, Seta, Otsu, Shiga 520-2192, Japan.
¹⁶ Department of Oncology, CHUV, Lausanne 1011, Switzerland.
¹⁷ Department of Gastroenterology, Netherlands Cancer Institute, Amsterdam 1066, The Netherlands.
¹⁸ Department of Oncology, University Hospital Zurich, Zurich 8091, Switzerland.
¹⁹ Department of Oncology, Luzerner Kantonsspital, Lucerne 6000, Switzerland.

PMID: 26313663
PMCID: PMC4559836
DOI: 10.1038/bjc.2015.279

Erratum in

Brain metastases in gastro-oesophageal adenocarcinoma: insights into the role of the human epidermal growth factor receptor 2 (HER2).
Feilchenfeldt J, Varga Z, Siano M, Grabsch HI, Held U, Schuknecht B, Trip A, Hamaguchi T, Gut P, Balague O, Khanfir K, Diebold J, Jochum W, Shoji H, Kushima R, Wagner D, Shimada Y, Cats A, Knuth A, Moch H, Aebi S, Hofer S. Feilchenfeldt J, et al. Br J Cancer. 2015 Dec 22;113(12):1747. doi: 10.1038/bjc.2015.458. Br J Cancer. 2015. PMID: 26695558 Free PMC article. No abstract available.

Abstract

Background: Gastro-oesophageal adenocarcinomas rarely metastasize to the central nervous system (CNS). The role of the human epidermal growth factor receptor 2 (HER2) in patients with these cancers and CNS involvement is presently unknown.

Patients and methods: A multicentre registry was established to collect data from patients with gastro-oesophageal adenocarcinomas and CNS involvement both retrospectively and prospectively. Inclusion in the study required a predefined clinical data set, a central neuro-radiological or histopathological confirmation of metastatic CNS involvement and central assessment of HER2 by immunohistochemistry (IHC) and in situ hybridisation (ISH). In addition, expression of E-cadherin and DNA mismatch repair (MMR) proteins were assessed by IHC.

Results: One hundred patients fulfilled the inclusion criteria. The population's median age was 59 years (interquartile range: 54-68), of which 85 (85%) were male. Twenty-five patients were of Asian and 75 of Caucasian origin. HER2 status was positive in 36% (95% CI: 26.6-46.2) of cases. Median time from initial diagnosis to the development of brain metastases (BMets) or leptomeningeal carcinomatosis (LC) was 9.9 months (95% CI: 8.5-15.0). Median overall survival from diagnosis was 16.9 months (95% CI: 14.0-20.7) and was not related to the HER2 status. E-cadherin loss was observed in 9% of cases and loss of expression in at least one DNA MMR proteins in 6%.

Conclusions: The proportion of a positive HER2 status in patients with gastro-oesophageal adenocarcinoma and CNS involvement was higher than expected. The impact of anti-HER2 therapies should be studied prospectively.

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References

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Brain metastases in gastro-oesophageal adenocarcinoma: insights into the role of the human epidermal growth factor receptor 2 (HER2)

Affiliations

Brain metastases in gastro-oesophageal adenocarcinoma: insights into the role of the human epidermal growth factor receptor 2 (HER2)

Authors

Affiliations

Erratum in

Abstract

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References

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LinkOut - more resources

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