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Editorial
. 2015 Oct;89(10):1881-93.
doi: 10.1007/s00204-015-1577-7. Epub 2015 Aug 28.

Toxicology: a discipline in need of academic anchoring--the point of view of the German Society of Toxicology

U Gundert-Remy  1 , H Barth  2 , A Bürkle  3 , G H Degen  4 , R Landsiedel  5
Affiliations
Editorial

Toxicology: a discipline in need of academic anchoring--the point of view of the German Society of Toxicology

U Gundert-Remy et al. Arch Toxicol. 2015 Oct.

Abstract

The paper describes the importance of toxicology as a discipline, its past achievements, current scientific challenges, and future development. Toxicological expertise is instrumental in the reduction of human health risks arising from chemicals and drugs. Toxicological assessment is needed to evaluate evidence and arguments, whether or not there is a scientific base for concern. The immense success already achieved by toxicological work is exemplified by reduced pollution of air, soil, water, and safer working places. Predominantly predictive toxicological testing is derived from the findings to assess risks to humans and the environment. Assessment of the adversity of molecular effects (including epigenetic effects), the effects of mixtures, and integration of exposure and biokinetics into in vitro testing are emerging challenges for toxicology. Toxicology is a translational science with its base in fundamental science. Academic institutions play an essential part by providing scientific innovation and education of young scientists.

Keywords: Academia; In silico toxicology; In vitro toxicology; Omics; Regulatory toxicology; Toxicology; Translational science.

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References

    1. Abakumov MA, Nukolova NV, Sokolsky-Papkov M, Shein SA, Sandalova TO, Vishwasrao HM, Grinenko NF, Gubsky IL, Abakumov AM, Kabanov AV, Chekhonin VP. VEGF-targeted magnetic nanoparticles for MRI visualization of brain tumor. Nanomedicine. 2015;11(4):825–833. doi: 10.1016/j.nano.2014.12.011. - DOI - PubMed
    1. Abraham K, Mielke H, Huisinga W, Gundert-Remy U. Elevated internal exposure of children in simulated acute inhalation of volatile organic compounds: effects of concentration and duration. Arch Toxicol. 2005;79(2):63–73. doi: 10.1007/s00204-004-0599-3. - DOI - PubMed
    1. Adler S, Basketter D, et al. Alternative (non-animal) methods for cosmetics testing: current status and future prospects—2010. Arch Toxicol. 2011;85(5):367–485. doi: 10.1007/s00204-011-0693-2. - DOI - PubMed
    1. Alépée N, Bahinski A, et al. State-of-the-art of 3D cultures (organs-on-a-chip) in safety testing and pathophysiology. ALTEX. 2014;31(4):441–477. - PMC - PubMed
    1. Alexeeff GV, Marty MA. Protection of infants, children, and other sensitive subpopulations. In: Howd RA, Fan AM, editors. Risk assessment for chemicals in drinking water. London: Wiley; 2008. pp. 171–200.

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