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Case Reports
. 2015 Aug 28;5(8):e343.
doi: 10.1038/bcj.2015.72.

Brentuximab vedotin: axonal microtubule's Apollyon

S Mariotto  1 , S Ferrari  1 , M Sorio  2 , F Benedetti  2 , G Tridente  3 , T Cavallaro  1 , A Gajofatto  1 , S Monaco  1
Affiliations
Case Reports

Brentuximab vedotin: axonal microtubule's Apollyon

S Mariotto et al. Blood Cancer J. .
No abstract available

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Figures

Figure 1
Figure 1
(a) A Spurr-embedded section of the sural nerve biopsy specimen shows reduction in density of myelinated fibers, degenerating axons and a few regenerating clusters, findings consistent with ongoing axonal neuropathy (scale bar=50 μm). (b) High magnification electron micrograph of a myelinated axon of the patient's sural nerve shows a few microtubule profiles oriented along the longitudinal axis of the fiber (arrowhead), in addition to tangentially oriented microtubules (arrow; scale bar=300 nm). (c) A myelinated fiber showing severe depletion of microtubules, bundles of misaligned neurofilaments and subaxolemmal segregation of smooth endoplasmic reticulum and membranous organelles (scale bar=120 nm). (d) A control myelinated fiber showing the typical alignment of the axonal cytoskeleton and the distribution of microtubules in distinct microdomains (scale bar=120 nm).
See this image and copyright information in PMC

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