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. 2016 Jan;68(1):247-54.
doi: 10.1002/art.39323.

Juvenile Idiopathic Arthritis in Olmsted County, Minnesota, 1960-2013

Megan L Krause  1 , Cynthia S Crowson  1 , C John Michet  1 , Thomas Mason  1 , Theresa Wampler Muskardin  1 , Eric L Matteson  1
Affiliations

Juvenile Idiopathic Arthritis in Olmsted County, Minnesota, 1960-2013

Megan L Krause et al. Arthritis Rheumatol. 2016 Jan.

Abstract

Objective: To evaluate the incidence and prevalence of juvenile idiopathic arthritis (JIA) in Olmsted County, Minnesota in 1994-2013 and trends in juvenile rheumatoid arthritis (JRA) in 1960-2013.

Methods: Cases of arthritis in 1994-2013 were identified by diagnosis code with medical chart review to confirm diagnosis separately for JIA and JRA. Overall incidence rates with 95% confidence intervals (95% CIs) were age and sex adjusted to the 2010 US white population. Comparisons were made with an earlier (1960-1993) cohort from this same population.

Results: Seventy-one incident cases of JIA in 1994-2013 were identified, with an overall age- and sex-adjusted incidence rate of 10.3 per 100,000 (95% CI 7.9-12.7). Forty-two (59%) were female, with an incidence of 12.4 per 100,000 (95% CI 8.6-16.2), as compared to 8.3 per 100,000 (95% CI 5.2-11.3) in males. The most common subtype was oligoarthritis (63%). The mean ± SD age at diagnosis was 8.2 ± 5.3 years. The prevalence of JIA on January 1, 2000 and January 1, 2010 was 51.0 per 100,000 (95% CI 25.2-76.8) and 57.6 per 100,000 (95% CI 31.0-94.5), respectively. When the annual incidence of JRA was compared over time from 1960 to 2013, there was no significant change in incidence overall; however, the incidence decreased among females (P = 0.003). A cyclic pattern of incidence was observed, with peaks approximately every 10 years. Similar to the findings with regard to incidence, prevalence did not change overall, but decreased among females (P = 0.048). There were 4 deaths in the cohort of JRA patients diagnosed in 1960-2013; the standardized mortality ratio was 1.50 (95% CI 0.41-3.83).

Conclusion: Incidence of juvenile arthritis overall in Olmsted County, Minnesota has not changed significantly in the past 53 years. A consistent cyclic pattern was noted.

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Figures

Figure 1
Figure 1
Annual incidence of juvenile rheumatoid arthritis (age adjusted to the 2010 US white population) among female residents (top) and male residents (bottom) of Rochester, Minnesota in 1960–1993 and of Olmsted County, Minnesota in 1994–2013.
Figure 2
Figure 2
Prevalence of juvenile rheumatoid arthritis (adjusted to the 2010 US white population) among female residents (top) and male residents (bottom) of Rochester, Minnesota on January 1, 1980 and January 1, 1990 and of Olmsted County, Minnesota on January 1, 2000 and January 1, 2010, by age group.
Figure 3
Figure 3
Survival among Olmsted County, Minnesota residents first diagnosed as having juvenile rheumatoid arthritis (JRA) between January 1, 1960 and December 31, 2013 (n = 118; solid line) compared to expected survival (dashed line). The standardized mortality ratio was 1.50 (95% confidence interval 0.41–3.83).
See this image and copyright information in PMC

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