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Review
. 2015 Sep;44(3):587-602.
doi: 10.1016/j.ecl.2015.05.007. Epub 2015 Jun 23.

The Effect of Menopausal Hormone Therapies on Breast Cancer: Avoiding the Risk

Valerie A Flores  1 , Hugh S Taylor  2
Affiliations
Review

The Effect of Menopausal Hormone Therapies on Breast Cancer: Avoiding the Risk

Valerie A Flores et al. Endocrinol Metab Clin North Am. 2015 Sep.

Abstract

Estrogen and P treatment results in greater risk of breast cancer than placebo. Treatment with estrogen alone does not increase the risk of breast cancer, may be used by women who have had a hysterectomy, and may even result in a decreased risk of breast cancer. Continued research seeks to improve the understanding of the interplay between estrogen and progestogens that predispose to adverse effects on breast tissue. Caution over this hypothesized benefit is warranted until it is substantiated by data on the incidence of breast cancer in tissue selective estrogen complex users.

Keywords: Breast cancer; Estrogens; Hormone therapy; Menopause; Progestogen.

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References

    1. Manson JE, Chlebowski RT, Stefanick ML, et al. Menopausal hormone therapy and health outcomes during the intervention and extended poststopping phases of the Women’s Health Initiative randomized trials. Jama. 2013;310(13):1353–1368. - PMC - PubMed
    1. Grady D, Rubin SM, Petitti DB, et al. Hormone therapy to prevent disease and prolong life in postmenopausal women. Ann Intern Med. 1992;117(12):1016–1037. - PubMed
    1. Chlebowski RT, Anderson GL, Gass M, et al. Estrogen plus progestin and breast cancer incidence and mortality in postmenopausal women. Jama. 2010;304(15):1684–1692. - PMC - PubMed
    1. Stefanick ML, Anderson GL, Margolis KL, et al. Effects of conjugated equine estrogens on breast cancer and mammography screening in postmenopausal women with hysterectomy. Jama. 2006;295(14):1647–1657. - PubMed
    1. Beral V. Breast cancer and hormone-replacement therapy in the Million Women Study. Lancet. 2003;362(9382):419–427. - PubMed