Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2016 Jun;10(2):256-60.
doi: 10.1007/s12105-015-0649-6. Epub 2015 Aug 28.

Olfactory Neuroblastoma: A Case Report

Heather R Olmo  1 , Steven Marc Stokes  2 , Robert D Foss  3
Affiliations
Case Reports

Olfactory Neuroblastoma: A Case Report

Heather R Olmo et al. Head Neck Pathol. 2016 Jun.

Abstract

A 43-year-old female presented with persistent nasal congestion with intermittent epistaxis without resolution for the preceding 5 years. Clinical examination revealed a large pink rubbery mass, medial to the middle turbinate in the right nasal cavity extending to the choana. Radiographic images demonstrated a heterogeneously enhancing lobular soft tissue mass filling the right nasal cavity, causing lateral bowing of the right medial orbital wall and extending posteriorly to the right anterior ethmoid sinus. The clinical, radiographic, histologic, and immunohistochemical features of olfactory neuroblastoma are discussed.

Keywords: Flexner-Wintersteiner rosettes; Homer Wright pseudorosettes; Nasal cavity; Olfactory neuroblastoma; Paranasal sinuses; Radiology.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Radiology of olfactory neuroblastoma. a CT coronal view. b CT sagittal view
Fig. 2
Fig. 2
Radiology of olfactory neuroblastoma. a MRI coronal view. b MRI sagittal view
Fig. 3
Fig. 3
The hematoxylin and eosin aspects of ONB. a Rounded nests of tumor cells set within a vascularized fibromyxoid stroma. b Formation of pseudorosettes with scattered neurofibrillary areas. c Tumor cells exhibit mild to moderate nuclear pleomorphism, fine chromatin, fibrillar cytoplasm, and scattered mitoses
Fig. 4
Fig. 4
Immunohistochemical features of ONB. a The tumor cells are strongly positive for synaptophysin. b S-100 highlighting the sustentactular cells at periphery of the tumor cell nets
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Berger L, Luc G, Richard D. L’esthesioneuorepitheliome olfatif. Bull Cancer. 1924;13:410–421.
    1. Berger L, Coutard H. L’esthesioneurocytome olfatif. Bull Assoc Etude Cancer. 1924;13:404–414.
    1. Wenig BM, Dulguerov P, Kapadia SB, Prasad ML, Fanburg-Smith JC, Thompson LD. Tumours of the nasal cavity and paranasal sinuses: neuroectodermal tumours. In: Barnes EL, Eveson JW, Reichart P, Sidransky D, editors. Pathology and genetics of head and neck tumours. In: Kleihues P, Sobin LH, series editors, Lyon: World Health Organization Classification of Tumours. IARC Press; 2005. p. 65–75.
    1. Thompson LD. Olfactory neuroblastoma. Head Neck Pathol. 2009;3(3):252–259. doi: 10.1007/s12105-009-0125-2. - DOI - PMC - PubMed
    1. Faragalla H, Weinreb I. Olfactory neuroblastoma: a review and update. Adv Anat Pathol. 2009;16(5):322–331. doi: 10.1097/PAP.0b013e3181b544cf. - DOI - PubMed

Publication types

Substances

LinkOut - more resources