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Case Reports
. 2016 Jun;10(2):256-60.
doi: 10.1007/s12105-015-0649-6. Epub 2015 Aug 28.

Olfactory Neuroblastoma: A Case Report

Heather R Olmo  1 , Steven Marc Stokes  2 , Robert D Foss  3
Affiliations
Case Reports

Olfactory Neuroblastoma: A Case Report

Heather R Olmo et al. Head Neck Pathol. 2016 Jun.

Abstract

A 43-year-old female presented with persistent nasal congestion with intermittent epistaxis without resolution for the preceding 5 years. Clinical examination revealed a large pink rubbery mass, medial to the middle turbinate in the right nasal cavity extending to the choana. Radiographic images demonstrated a heterogeneously enhancing lobular soft tissue mass filling the right nasal cavity, causing lateral bowing of the right medial orbital wall and extending posteriorly to the right anterior ethmoid sinus. The clinical, radiographic, histologic, and immunohistochemical features of olfactory neuroblastoma are discussed.

Keywords: Flexner-Wintersteiner rosettes; Homer Wright pseudorosettes; Nasal cavity; Olfactory neuroblastoma; Paranasal sinuses; Radiology.

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Figures

Fig. 1
Fig. 1
Radiology of olfactory neuroblastoma. a CT coronal view. b CT sagittal view
Fig. 2
Fig. 2
Radiology of olfactory neuroblastoma. a MRI coronal view. b MRI sagittal view
Fig. 3
Fig. 3
The hematoxylin and eosin aspects of ONB. a Rounded nests of tumor cells set within a vascularized fibromyxoid stroma. b Formation of pseudorosettes with scattered neurofibrillary areas. c Tumor cells exhibit mild to moderate nuclear pleomorphism, fine chromatin, fibrillar cytoplasm, and scattered mitoses
Fig. 4
Fig. 4
Immunohistochemical features of ONB. a The tumor cells are strongly positive for synaptophysin. b S-100 highlighting the sustentactular cells at periphery of the tumor cell nets
See this image and copyright information in PMC

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