Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2015 Jun;7(2):155-8.
doi: 10.4274/jcrpe.1740.

Dermal and Ophthalmic Findings in Pseudohypoaldosteronism

Sabriye Korkut  1 , Emir Gökalp, Ahmet Özdemir, Selim Kurtoğlu, Şafak Demirtaş, Ülkü Gül, Osman Baştuğ
Affiliations
Case Reports

Dermal and Ophthalmic Findings in Pseudohypoaldosteronism

Sabriye Korkut et al. J Clin Res Pediatr Endocrinol. 2015 Jun.

Abstract

Pseudohypoaldosteronism (PHA) is defined as a state of resistance to aldosterone, a hormone crucial for electrolyte equilibrium. The genetically transmitted type of PHA is primary hypoaldosteronism. Secondary hypoaldosteronism develops as a result of hydronephrosis or hydroureter. PHA patients suffer from severe hyponatremia and a severe clinical condition due to severe loss of salt can be encountered in the neonatal period. Dermal findings in the form of miliaria rubra can also develop in these patients. With the loss of salt, abnormal accumulation of sebum in the eye due to a defect in the sodium channels can also occur. In this paper, a case of PHA in a newborn showing typical dermatological and ophthalmological findings is presented.

PubMed Disclaimer

Figures

Figure 1
Figure 1. The appearance of the miliaria rubra on the trunk and arm.
Figure 2
Figure 2. The appearance of salt crystals at the base of the follicles of the face.
Figure 3
Figure 3. Presence of a white opaque discharge with an appearance of a row of teeth at the bottom of the eyelashes.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Riepe FG. Clinical and molecular features of type 1 pseudohypoaldosteronism. Horm Res. 2009;72:1–9. - PubMed
    1. Tütüncüler F, Günöz H, Bas F, Bundak R, Saka N, Neyzi O. Transient pseudohypoaldosteronism in an infant with urinary tract anomaly. Pediatr Int. 2004;46:618–620. - PubMed
    1. Büyükkayhan D, Köklü E, Görözen F, Kurtoğlu S, Hatipoğlu N, Gündüz Z. An endocrine problem of obstructive uropathy:pseudohypoaldosteronism. Erciyes Medical Journal. 2007;29:82–85.
    1. Geller DS. Mineralocorticoid resistance. Clin Endocrinol (Oxf) 2005;62:513–520. - PubMed
    1. Hanukoglu A. Type I pseudohypoaldosteronism includes two clinically and genetically distinct entities with either renal or multiple target organ defects. J Clin Endocrinol Metab. 1991;73:936–944. - PubMed

Publication types

Substances