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Review
. 2012:2012:729532.
doi: 10.1155/2012/729532. Epub 2012 Sep 19.

Molecular Markers with Predictive and Prognostic Relevance in Lung Cancer

Alphy Rose-James  1 , Sreelekha Tt  1
Affiliations
Review

Molecular Markers with Predictive and Prognostic Relevance in Lung Cancer

Alphy Rose-James et al. Lung Cancer Int. 2012.

Abstract

Lung cancer accounts for the majority of cancer-related deaths worldwide of which non-small-cell lung carcinoma alone takes a toll of around 85%. Platinum-based therapy is the stronghold for lung cancer at present. The discovery of various molecular alterations that underlie lung cancer has contributed to the development of specifically targeted therapies employing specific mutation inhibitors. Targeted chemotherapy based on molecular profiling has shown great promise in lung cancer treatment. Various molecular markers with predictive and prognostic significance in lung cancer have evolved as a result of advanced research. Testing of EGFR and Kras mutations is now a common practice among community oncologists, and more recently, ALK rearrangements have been added to this group. This paper discusses various predictive and prognostic markers that are being investigated and have shown significant relevance which can be exploited for targeted treatment in lung cancer.

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Figures

Figure 1
Figure 1
Major signalling pathways affected by altered genes in lung cancer.
Figure 2
Figure 2
Mutation spectra in lung adenocarcinoma.
Figure 3
Figure 3
Mutation spectra in squamous cell carcinoma.
See this image and copyright information in PMC

References

    1. Tran Y., Benbatoul K., Gorse K., et al. Novel regions of allelic deletion on chromosome 18p in tumors of the lung, brain and breast. Oncogene. 1998;17(26):3499–3505. - PubMed
    1. Sherbet G. W., Lakshi M. S. The Genetics of Cancer. San Diego, Calif, USA: Academic Press; 1997.
    1. Miura I., Graziano S. L., Jin Quan Cheng, Doyle L. A., Testa J. R. Chromosome alterations in human small cell lung cancer: frequent involvement of 5q. Cancer Research. 1992;52(5):1322–1328. - PubMed
    1. Testa J. R., Siegfried J. M. Chromosome abnormalities in human non-small cell lung cancer. Cancer Research. 1992;52(9, supplement):2702s–2706s. - PubMed
    1. Jarrard D. F., Bussemakers M. J. G., Bova G. S., Isaacs W. B. Regional loss of imprinting of the insulin-like growth factor II gene occurs in human prostate tissues. Clinical Cancer Research. 1995;1(12):1471–1478. - PubMed