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. 2015 Jun 1;2(2):202-210.
doi: 10.1007/s40472-015-0059-4.

New Tools in Experimental Cellular Therapy for the Treatment of Liver Diseases

Jennifer R Ferrer  1 , Attasit Chokechanachaisakul  2 , Jason A Wertheim  3
Affiliations

New Tools in Experimental Cellular Therapy for the Treatment of Liver Diseases

Jennifer R Ferrer et al. Curr Transplant Rep. .

Abstract

The current standard of care for end stage liver disease is orthotopic liver transplantation (OLT). Through improvement in surgical techniques, immunosuppression, and general medical care, liver transplantation has become an effective treatment over the course of the last half-century. Unfortunately, due to the limited availability of donor organs, there is a finite limit to the number of patients who will benefit from this therapy. This review will discuss current research in experimental cellular therapies for acute, chronic, and metabolic liver failure that may be appropriate when liver transplantation is not an immediate option.

Keywords: Alternative cell sources; Cellular therapy; Hepatocyte transplantation; Stem cells.

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Conflict of interest statement

Conflict of Interest Jennifer R. Ferrer and Attasit Chokechanachaisakul declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
Description of cell sources that have been investigated for use in hepatocyte transplantation
Fig. 2
Fig. 2
Isolation of primary human hepatocytes and implantation into a FAH −/− recipient allows for repopulation and restoration of liver function. (Reproduced with permission from [65]
See this image and copyright information in PMC

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