Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015;2(3):e774.
doi: 10.14800/rci.774.

Vascular protective effects of Angiotensin Receptor Blockers: Beyond Blood pressure

Sandeep Artham  1 , Abdelrahman Y Fouda  1 , Azza B El-Remessy  1 , Susan C Fagan  1
Affiliations

Vascular protective effects of Angiotensin Receptor Blockers: Beyond Blood pressure

Sandeep Artham et al. Receptors Clin Investig. 2015.
No abstract available

Keywords: ARB; VEGF; angiogenesis; candesartan; ischemic retinopathy; stroke; vascular protection.

PubMed Disclaimer

Conflict of interest statement

Conflicts of Interest: The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Schematic representation of the multiple pathways by which ARBs can regulate proangiogenic state including production of angiogenic factors, activation of HO-1 mediated angiogenic response, reduce oxidative and nitrative stress resulting in improved nitric oxide and stimulation of tip cells and pericyte and finally possible activation of AT2 receptor.
See this image and copyright information in PMC

References

    1. Guimond MO, Gallo-Payet N. How does angiotensin AT(2) receptor activation help neuronal differentiation and improve neuronal pathological situations? Front Endocrinol (Lausanne) 2012;3:164. - PMC - PubMed
    1. Sapieha P. Eyeing central neurons in vascular growth and reparative angiogenesis. Blood. 2012;120(11):2182–94. - PubMed
    1. Willis LM, El-Remessy AB, Somanath PR, Deremer DL, Fagan SC. Angiotensin receptor blockers and angiogenesis: clinical and experimental evidence. Clin Sci (Lond) 2011;120(8):307–19. - PubMed
    1. Priya MK, Sahu G, Soto-Pantoja DR, Goldy N, Sundaresan AM, Jadhav V, et al. Tipping off endothelial tubes: nitric oxide drives tip cells. Angiogenesis. 2014 - PMC - PubMed
    1. Gerhardt H, Golding M, Fruttiger M, Ruhrberg C, Lundkvist A, Abramsson A, et al. VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia. J Cell Biol. 2003;161(6):1163–77. - PMC - PubMed

LinkOut - more resources