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. 2015 Aug 27;162(5):937.
doi: 10.1016/j.cell.2015.07.045.

PD-1 Blockers

Jedd D Wolchok  1
Affiliations
Free article

PD-1 Blockers

Jedd D Wolchok. Cell. .
Free article

Abstract

Nivolumab and pembrolizumab are monoclonal antibodies that block the programmed death-1 receptor (PD-1, CD279), resulting in dis-inhibition of tumor-specific immune responses. Both are recently approved for use in the treatment of metastatic melanoma, and nivolumab as well for non-small cell lung cancer.

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