Comment
doi: 10.1016/j.cell.2015.08.005.
DNA Methylation Inhibitors in Cancer Therapy: The Immunity Dimension
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- PMID: 26317460
- DOI: 10.1016/j.cell.2015.08.005
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DNA Methylation Inhibitors in Cancer Therapy: The Immunity Dimension
Cell.
.
Free article
Abstract
DNA demethylating agents are approved for some blood malignancies and are under active investigation in solid tumors, but how these drugs work has remained unclear. In this issue of Cell, two groups show that these agents activate a toxic cellular antiviral program through transcriptional activation of endogenous retroviral sequences.
Copyright © 2015 Elsevier Inc. All rights reserved.
Comment on
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DNA-Demethylating Agents Target Colorectal Cancer Cells by Inducing Viral Mimicry by Endogenous Transcripts.Cell. 2015 Aug 27;162(5):961-73. doi: 10.1016/j.cell.2015.07.056. Cell. 2015. PMID: 26317465 Free PMC article.
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Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses.Cell. 2015 Aug 27;162(5):974-86. doi: 10.1016/j.cell.2015.07.011. Cell. 2015. PMID: 26317466 Free PMC article.
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